Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study

Sayuri Shima; Yasuaki Mizutani; Junichiro Yoshimoto; Yasuhiro Maeda; Reiko Ohdake; Ryunosuke Nagao; Toshiki Maeda; Atsuhiro Higashi; Akihiro Ueda; Mizuki Ito; Tatsuro Mutoh; Hirohisa Watanabe

doi:10.20944/preprints202311.0450.v1

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preprints.org > medicine and pharmacology > neuroscience and neurology > doi: 10.20944/preprints202311.0450.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study

Version 1 : Received: 7 November 2023 / Approved: 7 November 2023 / Online: 8 November 2023 (01:42:47 CET)

How to cite: Shima, S.; Mizutani, Y.; Yoshimoto, J.; Maeda, Y.; Ohdake, R.; Nagao, R.; Maeda, T.; Higashi, A.; Ueda, A.; Ito, M.; Mutoh, T.; Watanabe, H. Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study. Preprints 2023, 2023110450. https://doi.org/10.20944/preprints202311.0450.v1 Shima, S.; Mizutani, Y.; Yoshimoto, J.; Maeda, Y.; Ohdake, R.; Nagao, R.; Maeda, T.; Higashi, A.; Ueda, A.; Ito, M.; Mutoh, T.; Watanabe, H. Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study. Preprints 2023, 2023110450. https://doi.org/10.20944/preprints202311.0450.v1

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MDPI and ACS Style

Shima, S.; Mizutani, Y.; Yoshimoto, J.; Maeda, Y.; Ohdake, R.; Nagao, R.; Maeda, T.; Higashi, A.; Ueda, A.; Ito, M.; Mutoh, T.; Watanabe, H. Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study. Preprints 2023, 2023110450. https://doi.org/10.20944/preprints202311.0450.v1

APA Style

Shima, S., Mizutani, Y., Yoshimoto, J., Maeda, Y., Ohdake, R., Nagao, R., Maeda, T., Higashi, A., Ueda, A., Ito, M., Mutoh, T., & Watanabe, H. (2023). Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study. Preprints. https://doi.org/10.20944/preprints202311.0450.v1

Chicago/Turabian Style

Shima, S., Tatsuro Mutoh and Hirohisa Watanabe. 2023 "Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study" Preprints. https://doi.org/10.20944/preprints202311.0450.v1

Abstract

The phenomenon of decreased serum uric acid (UA) levels in patients with Parkinson’s disease (PD) and its relationship with purine metabolic pathways remain unclear. We compared inosine, hy-poxanthine, xanthine, and UA levels in serum and cerebrospinal fluid (CSF) of PD patients with those of controls, and investigated the effect of changes in the purine metabolic system on UA levels in PD. Overall, 134 samples (serum, 45 PD patients and 30 controls; CSF, 39 PD patients and 20 controls), were analyzed using liquid chromatography-tandem mass spectrometry. A general linear model (GLM) was used to investigate relationships among purine metabolites. Compared to controls, PD patients had significantly lower UA levels in the serum and CSF, and serum and CSF UA levels were significantly correlated. Additionally, in PD, decreased serum hypoxanthine levels were observed with decreased CSF inosine and hypoxanthine levels, suggesting the involvement of the purine recycling system. GLM analysis indicated that the reduced UA levels in PD were mainly due to sources other than the purine metabolic system, such as exercise, nutritional indices, muscle volume, or adipose tissue. Our results highlight the impairment of purine recycling pathways in PD, as evidenced by the decreased serum hypoxanthine and CSF inosine.

Keywords

uric acid; purine recycling disorders; Parkinson’s disease; cerebrospinal fluid; general linear model

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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