Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Determination of Peak Oxygen Uptake in Patients with Acute Myocardial Infarction: The Role of Arterial Stiffness in the Cardio-Vascular-Skeletal Muscle Coupling

Akihiro Ogawa
* ORCID logo ,
Shinya Kanzaki
,
Yuki Ikeda
,
Masahiro Iwakawa
,
Takahiro Nakagami
,
Shuji Sato
,
Hiroshi Mikamo
,
Satoshi Kido
,
Arata Nakajima
,
Kazuhiro Shimizu
ORCID logo
Version 1 : Received: 2 November 2023 / Approved: 2 November 2023 / Online: 3 November 2023 (09:07:52 CET)

A peer-reviewed article of this Preprint also exists.

Ogawa, A.; Kanzaki, S.; Ikeda, Y.; Iwakawa, M.; Nakagami, T.; Sato, S.; Mikamo, H.; Kido, S.; Nakajima, A.; Shimizu, K. Determination of Peak Oxygen Uptake in Patients with Acute Myocardial Infarction: The Role of Arterial Stiffness in Cardio–Vascular–Skeletal Muscle Coupling. J. Clin. Med. 2024, 13, 42. Ogawa, A.; Kanzaki, S.; Ikeda, Y.; Iwakawa, M.; Nakagami, T.; Sato, S.; Mikamo, H.; Kido, S.; Nakajima, A.; Shimizu, K. Determination of Peak Oxygen Uptake in Patients with Acute Myocardial Infarction: The Role of Arterial Stiffness in Cardio–Vascular–Skeletal Muscle Coupling. J. Clin. Med. 2024, 13, 42.

Abstract

The relationship between arterial stiffness and oxygen uptake (VO2) in patients with acute myocardial infarction (AMI) remains unclear. We aimed to investigate this relationship and factors contributing to VO2 in patients with AMI. The role of arterial stiffness in cardiac-skeletal muscle coupling during exercise was then elucidated. The exercise capacity via cardiopulmonary exercise testing (CPX), cardio-ankle vascular index (CAVI), and body composition of 101 patients with AMI were measured at discharge. Patients were categorized based on their CAVI into three groups: (i) normal (CAVI: ≤7.9), (ii) borderline (CAVI: 8.0–8.9), and (iii) abnormal (CAVI: ≥9.0). Subsequently, VO2 was compared among these groups. The relationship between the CAVI and peak VO2 (VO2 Peak) during CPX and factors contributing to VO2 Peak were investigated. The abnormal CAVI group had a significantly lower VO2 Peak than the normal and borderline groups. The CAVI was associated with VO2 Peak in patients with AMI. Furthermore, the CAVI was found to be a factor contributing to VO2 Peak. These findings suggest that arterial stiffness in tissue blood distribution and blood supply defines systemic exercise limits in patients with AMI. This suggested that arterial stiffness plays a significant role in cardio-vascular-skeletal muscle coupling.

Keywords

cardio-ankle vascular index; acute myocardial infarction; VO2 Peak; cardio-vascular-skeletal muscle coupling

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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