Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Thyme Essential Oil As an Antibacterial Irrigant in Root Canal Treatment: In Vitro Preliminary Study

Michela Galgano
,
Francesco Pellegrini
ORCID logo ,
Laura Del Sambro
,
Loredana Capozzi
,
Paolo Capozza
ORCID logo ,
Angelica Bianco
,
Alfredo Iandolo
,
Ahmed Hassan Omar
ORCID logo ,
Antonio Parisi
,
Annamaria Pratelli
* ORCID logo ,
Alessio Buonavoglia
ORCID logo
Version 1 : Received: 31 October 2023 / Approved: 1 November 2023 / Online: 1 November 2023 (13:13:03 CET)

How to cite: Galgano, M.; Pellegrini, F.; Del Sambro, L.; Capozzi, L.; Capozza, P.; Bianco, A.; Iandolo, A.; Omar, A.H.; Parisi, A.; Pratelli, A.; Buonavoglia, A. Thyme Essential Oil As an Antibacterial Irrigant in Root Canal Treatment: In Vitro Preliminary Study. Preprints 2023, 2023110078. https://doi.org/10.20944/preprints202311.0078.v1 Galgano, M.; Pellegrini, F.; Del Sambro, L.; Capozzi, L.; Capozza, P.; Bianco, A.; Iandolo, A.; Omar, A.H.; Parisi, A.; Pratelli, A.; Buonavoglia, A. Thyme Essential Oil As an Antibacterial Irrigant in Root Canal Treatment: In Vitro Preliminary Study. Preprints 2023, 2023110078. https://doi.org/10.20944/preprints202311.0078.v1

Abstract

Irrigation is crucial in cleaning and disinfection of the root canal system, because endodontic instruments are unable to reach a large part of the root canal system (isthmuses, accessory canals, apical ramifications) and bacteria that can reside. Sodium hypochlorite (NaOCl) is currently used as irrigant in root canal therapies for its non-specific protheolytic and antimicrobial properties, but undesirable effects may be observed especially when used near the terminus of apical foramen. This study aims to evaluate antimicrobial properties of Thyme Essential Oil (TEO) used alone or in combination with NaOCl against different bacterial strains, especially Staphylococcus aureus and Streptococcus mutans. TEO non-cytotoxic concentration (9,28mg/mL) showed antimicrobial properties comparable to NaOCl after 1min of contact, both in presence of organic material (6% sheep blood). Moreover, the combination of TEO and NaOCl did not compromise their individual antimicrobial properties at the same time of contact. These data suggest that TEO could be used as antimicrobial irrigant in root canal therapies in association with NaOCl, to reduce concentration of NaOCl and its undesirable side effects. Due to the absence of cytotoxic effects at tested dilution, TEO could be safely used also near the terminus of apical foramen for its cytocompatibility.

Keywords

Root canal system; antibacterial; irrigants; Thyme Essential Oil; Sodium Hypochlorite

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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