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Effect of the Consumption of Vitamin C, D3, CA Supplements and Olive Paste Enriched with Mountain Tea on Bone Metabolism Indices in Postmenopausal Women with Increased Osteoporosis’ Risk: A Prospective Interven-Tional Study
Version 1
: Received: 31 October 2023 / Approved: 31 October 2023 / Online: 31 October 2023 (12:25:22 CET)
How to cite:
Konstantinidi, M.; Stoupi, S.; Anastasiou, I.; Nikolaos, V.; Tsakotos, G.; Koutelidakis, A.E. Effect of the Consumption of Vitamin C, D3, CA Supplements and Olive Paste Enriched with Mountain Tea on Bone Metabolism Indices in Postmenopausal Women with Increased Osteoporosis’ Risk: A Prospective Interven-Tional Study. Preprints2023, 2023102094. https://doi.org/10.20944/preprints202310.2094.v1
Konstantinidi, M.; Stoupi, S.; Anastasiou, I.; Nikolaos, V.; Tsakotos, G.; Koutelidakis, A.E. Effect of the Consumption of Vitamin C, D3, CA Supplements and Olive Paste Enriched with Mountain Tea on Bone Metabolism Indices in Postmenopausal Women with Increased Osteoporosis’ Risk: A Prospective Interven-Tional Study. Preprints 2023, 2023102094. https://doi.org/10.20944/preprints202310.2094.v1
Konstantinidi, M.; Stoupi, S.; Anastasiou, I.; Nikolaos, V.; Tsakotos, G.; Koutelidakis, A.E. Effect of the Consumption of Vitamin C, D3, CA Supplements and Olive Paste Enriched with Mountain Tea on Bone Metabolism Indices in Postmenopausal Women with Increased Osteoporosis’ Risk: A Prospective Interven-Tional Study. Preprints2023, 2023102094. https://doi.org/10.20944/preprints202310.2094.v1
APA Style
Konstantinidi, M., Stoupi, S., Anastasiou, I., Nikolaos, V., Tsakotos, G., & Koutelidakis, A.E. (2023). Effect of the Consumption of Vitamin C, D3, CA Supplements and Olive Paste Enriched with Mountain Tea on Bone Metabolism Indices in Postmenopausal Women with Increased Osteoporosis’ Risk: A Prospective Interven-Tional Study. Preprints. https://doi.org/10.20944/preprints202310.2094.v1
Chicago/Turabian Style
Konstantinidi, M., George Tsakotos and Antonios E. Koutelidakis. 2023 "Effect of the Consumption of Vitamin C, D3, CA Supplements and Olive Paste Enriched with Mountain Tea on Bone Metabolism Indices in Postmenopausal Women with Increased Osteoporosis’ Risk: A Prospective Interven-Tional Study" Preprints. https://doi.org/10.20944/preprints202310.2094.v1
Abstract
(1) Background : Low dietary intake of calcium, vitamin D, vitamin C and magnesium has been associated with increased risk of osteoposrosis. The purpose was to evaluate changes in biomarkers of bone metabolism, and cardiometabolic health in postmenopausal women, with high risk of osteoporosis, followed by a nutritional intervention program. (2) Method: It was a prospective randomized controlled trial. A sample of 115 apparently healthy postmenopausal women(45 -75 years of age) randomized into four groups: (I) nutritional intervention group(n=40) received daily 1000mg vitamin C, 500mg vitamin D3, 500mg calcium(Ca) and 300mg magnesium (Mg); (II) control group(n=42) received daily 500mg vitamin D3, 500mg Ca and 300mg Mg; (III) nutritional intervention group (n=18) received daily 150mg bisphosphonates, 500mg vitamin D3, 500mg Ca and 300mg Mg; and (IV) nutritional intervention group (n=15) received daily about 364 mg polyphenols via an innovative functional food (50g olive paste enriched with mountain tea extract) along with 500mg vitamin D3, 500mg Ca and 300mg Mg. Groups I -III received supplementation for a year whereas group IV for 5 months. Changes in calciregulatory hormone parathormone (PTH) were evaluated at the beginning of the study as well as at 5 and 12 months intervals. Blood levels of vitamin D, vitamin C, Ca, Mg and the lipid profile were assessed at the beginning and at the end of the study. Anthropometric indices (weight, body fat(Kg), Body Mass Index(BMI) and bone mineral density(BMD) were evaluated at the beginning and at the end of the study. Statistical analysis was performed with IBM-SPSS Statistics-21. The level of statistical significance was set at p<0.05. (3) Results: 25(OH)D3 levels were improved, in groups II, III and IV (+3,71% and +1.45% and +5.62% respectively). PTH levels were increased at the end of the intervention period, for groups I and IV. Significant positive changes recorded, in total BMD, in all four study groups. Significant beneficial changes for total cholesterol was observed in group IV (-2.07%, P<0.05) and positive changes in group I for HDL biomarker (+61.62%, P<0.05) (4) Conclusions:. Additional larger-scale clinical trials and intervention studies are considered essential, in order to fully investigate and elucidate associations between dietary components and biochemical indices of bone metabolism.
Keywords
micronutients; functional foods; olive paste; bone mineral density; bone metabolism biomarkers; postmenopausal women
Subject
Public Health and Healthcare, Health Policy and Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
