Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Factors Associated with Poor Quality of Life in Breast Cancer Survivors: A 3-Year Follow-Up Study

Version 1 : Received: 30 October 2023 / Approved: 30 October 2023 / Online: 30 October 2023 (13:51:16 CET)

A peer-reviewed article of this Preprint also exists.

Kim, S.-H.; Jo, H.-Y. Factors Associated with Poor Quality of Life in Breast Cancer Survivors: A 3-Year Follow-Up Study. Cancers 2023, 15, 5809. Kim, S.-H.; Jo, H.-Y. Factors Associated with Poor Quality of Life in Breast Cancer Survivors: A 3-Year Follow-Up Study. Cancers 2023, 15, 5809.

Abstract

The purpose of this study was to identify subgroups of quality of life (QOL) changes in breast cancer survivors (BCS) and to determine factors associated with subgroups of consistently low or deteriorated QOL. We enrolled 101 women recently diagnosed with breast cancer in South Korea and asked them to complete a questionnaire at baseline (within 1 month of diagnosis), 1 year later (Year 1), 2 years later (Year 2), and 3 years later (Year 3). We assessed QOL using the global QOL subscale from the EORTC QLQ-C30. We defined low QOL as a global QOL score 10 points below the mean score of the general population. Based on low QOL as defined in this study, we identified subgroups of QOL changes over 3 years. We identified four subgroups of QOL changes: improved (47.4%), stable (30%), continuously low (8.8%), and deteriorated (13.8%) and considered the last two categories (22.6%) as poor QOL. Logistic regression analyses demonstrated that significant determinants of poor QOL were insomnia at Year 1, fatigue and anxiety at Year 2, and fatigue, depression, and comorbidity at Year 3. In conclusion, persistent symptoms of insomnia, fatigue, anxiety, depression, and comorbidity are potential risk factors for poor QOL in BCS.

Keywords

breast cancer; depression; fatigue; insomnia; quality of life

Subject

Public Health and Healthcare, Nursing

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