Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Navigating the Labyrinth: Intensive Care Challenges in Patients with Acute on Chronic Liver Failure

Fuat H. Saner
* ORCID logo ,
Dimitri A. Raptis
ORCID logo ,
Saad Ali Alghamdi
,
Massimo M. Malagó
,
Dieter C. Broering
,
Dmitri Bezinover
Version 1 : Received: 27 October 2023 / Approved: 30 October 2023 / Online: 30 October 2023 (11:17:47 CET)

A peer-reviewed article of this Preprint also exists.

Saner, F.H.; Raptis, D.A.; Alghamdi, S.A.; Malagó, M.M.; Broering, D.C.; Bezinover, D. Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure. Journal of Clinical Medicine 2024, 13, 506, doi:10.3390/jcm13020506. Saner, F.H.; Raptis, D.A.; Alghamdi, S.A.; Malagó, M.M.; Broering, D.C.; Bezinover, D. Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure. Journal of Clinical Medicine 2024, 13, 506, doi:10.3390/jcm13020506.

Abstract

Acute-on-Chronic Liver Failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short-term mortality. Optimal medical management of patients with ACLF requires implementing complex treatment strategies, often in an intensive care unit (ICU). Failure of organs other than the liver distinguishes ACLF from other critical illnesses. Although there is growing evidence supporting the current approach of ACLF management, mortality associated with this condition remains unacceptably high. In this review, we discuss considerations for ICU care of patients with ACLF and highlight areas for further research.

Keywords

cirrhosis; hemostasis disorder; ICU treatment; hemodynamic disorder; infection

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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