Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Lycopene Mitigates Malaria-Induced Reactive Oxygen Nitrogen Species Formation and Oxidative Damage in Mice Brain and Lungs

Everton Luiz Pompeu Varela
,
Antônio Rafael Quadros Gomes
ORCID logo ,
Aline Da Silva Barbosa dos Santos
,
Mariana Dos Santos Guimarães
,
Eliete Pereira de Carvalho
,
Oberdan Oliveira Ferreira
,
Mozaniel Santana de Oliveira
ORCID logo ,
Eloisa Helena De Aguiar Andrade
ORCID logo ,
Sandro Percário
* ORCID logo
Version 1 : Received: 22 October 2023 / Approved: 23 October 2023 / Online: 23 October 2023 (15:23:27 CEST)

How to cite: Varela, E.L.P.; Gomes, A.R.Q.; Da Silva Barbosa dos Santos, A.; Dos Santos Guimarães, M.; Pereira de Carvalho, E.; Oliveira Ferreira, O.; Santana de Oliveira, M.; De Aguiar Andrade, E.H.; Percário, S. Lycopene Mitigates Malaria-Induced Reactive Oxygen Nitrogen Species Formation and Oxidative Damage in Mice Brain and Lungs. Preprints 2023, 2023101422. https://doi.org/10.20944/preprints202310.1422.v1 Varela, E.L.P.; Gomes, A.R.Q.; Da Silva Barbosa dos Santos, A.; Dos Santos Guimarães, M.; Pereira de Carvalho, E.; Oliveira Ferreira, O.; Santana de Oliveira, M.; De Aguiar Andrade, E.H.; Percário, S. Lycopene Mitigates Malaria-Induced Reactive Oxygen Nitrogen Species Formation and Oxidative Damage in Mice Brain and Lungs. Preprints 2023, 2023101422. https://doi.org/10.20944/preprints202310.1422.v1

Abstract

(1) Background: The severity of malaria is associated with low bioavailability of antioxidants and high concentration of free radicals that induce oxidative damage in cerebral and pulmonary microcirculation. This can be prevented by the action of consumable antioxidants present in foods. Therefore, we investigated the protective role of lycopene (LYC) on the oxidative changes induced by Plasmodium berghei (Pb); (2) Methods: Mice were infected by intraperitoneal injection of 106 parasitized red blood cells and treated via gavage with LYC (3.11 mg/kg bw/day) or NAC (62 mg/kg bw/day). They were then evaluated for 1, 4, 8 or 12 days after infection. Levels of thiobarbituric acid reactive substances (TBARS), antioxidant capacity by inhibition of ABTS radicals (AC-ABTS) and DPPH (AC-DPPH), uric acid (UA), and nitric oxide (NO) were measured in brain and lung tissues; (3) Results: The infection caused oxidative stress confirmed by increased levels of TBARS, AC-ABTS, AC-DPPH, UA, and NO in the tissues leading to the death of the animals. LYC prevented the increase in TBARS, AU, and NO levels compared to Pb (p< 0.0001) and NAC+Pb groups (p<0.0001), reaching values similar to those of Sham animals; (4) Conclusions: These results are striking evidence of the beneficial effect of lycopene supplementation on oxidative stress in experimental malaria in vivo and emphasize the importance of antioxidant supplementation in the treatment of the disease.

Keywords

Lycopene; N-Acetylcysteine; Malaria; Oxidative stress; Antioxidant

Subject

Biology and Life Sciences, Parasitology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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