Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Metabolite Profiling of Allium hookeri Leaves using UPLC-qTOF-MS/MS and Senomorphic Activity of Phenolamides

Thi-Phuong Doan
ORCID logo ,
Mi Zhang
,
Jin-Pyo An
,
Jorge-Eduardo Ponce-Zea
ORCID logo ,
Van-Hieu Mai
,
Byeol Ryu
ORCID logo ,
Eun Jin Park
,
And Won-Keun Oh
* ORCID logo
Version 1 : Received: 14 October 2023 / Approved: 16 October 2023 / Online: 17 October 2023 (08:12:53 CEST)

A peer-reviewed article of this Preprint also exists.

Doan, T.-P.; Zhang, M.; An, J.-P.; Ponce-Zea, J.-E.; Mai, V.-H.; Ryu, B.; Park, E.-J.; Oh, W.-K. Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides. Nutrients 2023, 15, 5109. Doan, T.-P.; Zhang, M.; An, J.-P.; Ponce-Zea, J.-E.; Mai, V.-H.; Ryu, B.; Park, E.-J.; Oh, W.-K. Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides. Nutrients 2023, 15, 5109.

Abstract

The plant Allium hookeri, belonging to the Allium genus, has a history of being used both as a common food ingredient and in herbal medicine. It has recently been reported to have anti-oxidant and anti-inflammatory effects. A. hookeri has been also shown to exhibit neuroprotective and anti-neuroinflammatory activities, but the active compounds responsible for these effects have not been identified in previous studies. This study aimed to perform a metabolite profiling using an HRESI-qTOF MS/MS-based molecular networking approach and identify the active compounds from A. hookeri that target senescent cell-associated secretory phenotype (SASP) inhibitory effects, which contribute to neuroprotective activities. As a result, ten compounds, including one new flavonoid (2) and nine known compounds (1 and 3–10), were identified, and their biological activity was tested. The most potent compound was N-trans-feruloyltyramine (7), which inhibited SASP markers and contributed to the senomorphic activities of A. hookeri. These findings suggest that the phenolamides from A. hookeri could be a promising source of bioactive compounds for preventing senescence-associated diseases.

Keywords

Allium hookeri; N-trans-feruloyltyramine; senomorphic effect; SASP inhibitor

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.