Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Metabolite Profiling of Allium hookeri Leaves using UPLC-qTOF-MS/MS and Senomorphic Activity of Phenolamides

Thi-Phuong Doan
ORCID logo ,
Mi Zhang
,
Jin-Pyo An
,
Jorge-Eduardo Ponce-Zea
ORCID logo ,
Van-Hieu Mai
,
Byeol Ryu
ORCID logo ,
Eun Jin Park
,
And Won-Keun Oh
* ORCID logo
Version 1 : Received: 14 October 2023 / Approved: 16 October 2023 / Online: 17 October 2023 (08:12:53 CEST)

A peer-reviewed article of this Preprint also exists.

Doan, T.-P.; Zhang, M.; An, J.-P.; Ponce-Zea, J.-E.; Mai, V.-H.; Ryu, B.; Park, E.-J.; Oh, W.-K. Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides. Nutrients 2023, 15, 5109. Doan, T.-P.; Zhang, M.; An, J.-P.; Ponce-Zea, J.-E.; Mai, V.-H.; Ryu, B.; Park, E.-J.; Oh, W.-K. Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides. Nutrients 2023, 15, 5109.

Abstract

The plant Allium hookeri, belonging to the Allium genus, has a history of being used both as a common food ingredient and in herbal medicine. It has recently been reported to have anti-oxidant and anti-inflammatory effects. A. hookeri has been also shown to exhibit neuroprotective and anti-neuroinflammatory activities, but the active compounds responsible for these effects have not been identified in previous studies. This study aimed to perform a metabolite profiling using an HRESI-qTOF MS/MS-based molecular networking approach and identify the active compounds from A. hookeri that target senescent cell-associated secretory phenotype (SASP) inhibitory effects, which contribute to neuroprotective activities. As a result, ten compounds, including one new flavonoid (2) and nine known compounds (1 and 3–10), were identified, and their biological activity was tested. The most potent compound was N-trans-feruloyltyramine (7), which inhibited SASP markers and contributed to the senomorphic activities of A. hookeri. These findings suggest that the phenolamides from A. hookeri could be a promising source of bioactive compounds for preventing senescence-associated diseases.

Keywords

Allium hookeri; N-trans-feruloyltyramine; senomorphic effect; SASP inhibitor

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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