Vincze, M.; Sikovanyecz, J., Jr.; Molnár, A.; Földesi, I.; Surányi, A.; Várbíró, S.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome. Medicina2024, 60, 85.
Vincze, M.; Sikovanyecz, J., Jr.; Molnár, A.; Földesi, I.; Surányi, A.; Várbíró, S.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome. Medicina 2024, 60, 85.
Vincze, M.; Sikovanyecz, J., Jr.; Molnár, A.; Földesi, I.; Surányi, A.; Várbíró, S.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome. Medicina2024, 60, 85.
Vincze, M.; Sikovanyecz, J., Jr.; Molnár, A.; Földesi, I.; Surányi, A.; Várbíró, S.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome. Medicina 2024, 60, 85.
Abstract
Introduction: An increasing body of evidence shows the significant role of the angiogenic factor levels in screening of pregnancy outcome. Purpose: To examine the potential relationship between concentrations of placental protein 13 (PP13) and soluble Human Leukocyte Antigen-G (sHLA-G) in maternal serum and amniotic fluid at 16-23 weeks of gestation and the sonographic features of pregnancy as well as pregnancy outcome. Materials and methods: PP13 and sHLA-G in serum and amniotic fluid, and fetal biometrical data and placental volume and perfusion indices were determined in 71 euploid, singleton pregnancies. Results: The serum sHLA-G level correlated negatively with serum PP13 level (r = -0.186, p<0.001) and positively with sHLA-G level in the amniotic fluid (r = 0.662, p<0.001). Significant correlation was found between serum sHLA-G level and placental volume (r = 0.142, p<0.05) and between amniotic sHLA-G level and placental perfusion (r = -0.450, p<0.001). A low amniotic PP13 level significantly predicted the birth weight (r = -0.102, p<0.05), the duration of pregnancy (r = -0.155, p<0.05), and the fetal abdominal circumference (r=-0.098, p<0.05). Conclusions: PP13 assayed in amniotic fluid might be a potential marker of fetal growth and sHLA-G can be an adjunct modality reflecting placental sonographic parameters.
Keywords
soluble Human Leukocyte Antigen-G; placental protein-13; serum; amniotic fluid; sonography
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
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