Version 1
: Received: 10 October 2023 / Approved: 11 October 2023 / Online: 13 October 2023 (07:12:22 CEST)
How to cite:
Medina Bueno, G.A.; Fernández-Montolí, M.E.; Ponce Sebastià, J.; Peñafiel Muñoz, J. Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3. Preprints2023, 2023100703. https://doi.org/10.20944/preprints202310.0703.v1
Medina Bueno, G.A.; Fernández-Montolí, M.E.; Ponce Sebastià, J.; Peñafiel Muñoz, J. Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3. Preprints 2023, 2023100703. https://doi.org/10.20944/preprints202310.0703.v1
Medina Bueno, G.A.; Fernández-Montolí, M.E.; Ponce Sebastià, J.; Peñafiel Muñoz, J. Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3. Preprints2023, 2023100703. https://doi.org/10.20944/preprints202310.0703.v1
APA Style
Medina Bueno, G.A., Fernández-Montolí, M.E., Ponce Sebastià, J., & Peñafiel Muñoz, J. (2023). Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3. Preprints. https://doi.org/10.20944/preprints202310.0703.v1
Chicago/Turabian Style
Medina Bueno, G.A., Jordi Ponce Sebastià and Judith Peñafiel Muñoz. 2023 "Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3" Preprints. https://doi.org/10.20944/preprints202310.0703.v1
Abstract
Objectives: To evaluate the relationship between the type of conization, the volume and dimensions of the cone, with the persistence/recurrence of CIN 2-3, presence of affected margins and post-cone HR-HPV positivity.
Methods: 227 women treated with LLETZ and histologically confirmed CIN2-3 were evaluated between 1996 and 2006 and followed up until June 2016. Age, type of resection according to IFCPC 2011, volume, cone dimensions, margins were studied. of resection, post-cone high-risk human papillomavirus (HR-HPV) status and viral load. Determinants of HR-HPV positivity were estimated using unconditional logistic regression and time to recurrence was assessed using Kaplan-Meier curves.
Results: Persistent/recurrent CIN2-3 was found in 12 cases (5.2%), type 1 conization was performed in 81 patients, with 5 recurrences (6.1%), type 2 in 101 patients, with 6 recurrences (5 .9%) and type 3 resection in 45 women, with 1 recurrence (2.2%). Volume and dimensions were not associated with recurrence. The Log-Rank Test did not show a significant difference between the 3 treatments (p= 0.18). The free margins in type 1 were 37%, in type 2 resection 61% and in type 3 71% (p=0.001). Resection type 1 had 15% HR-HPV post positive cone, type 2 reached 16% and type 3 had 9%, this difference being non-significant (p=0.58). The incidence of recurrence at 36 months in type 1 resection was 0.08%, in type 2 treatment it was 0.04% and in type 3 resection it was 0.0%.
Conclusions : Type 3 resection had a higher proportion of free margins and lower post-cone HR-HPV positivity, with a lower incidence of persistence/recurrence.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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