Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficacy and Safety of LASERs in Treatment of Dermal Pigmentation: A Five-Year Experience of 122 patients from North India

Version 1 : Received: 29 September 2023 / Approved: 9 October 2023 / Online: 10 October 2023 (10:23:38 CEST)

How to cite: Garg, S.; Garg, D.; Oberoi, B.; Sharma, G. Efficacy and Safety of LASERs in Treatment of Dermal Pigmentation: A Five-Year Experience of 122 patients from North India. Preprints 2023, 2023100539. https://doi.org/10.20944/preprints202310.0539.v1 Garg, S.; Garg, D.; Oberoi, B.; Sharma, G. Efficacy and Safety of LASERs in Treatment of Dermal Pigmentation: A Five-Year Experience of 122 patients from North India. Preprints 2023, 2023100539. https://doi.org/10.20944/preprints202310.0539.v1

Abstract

Dermal pigmentation is a challenging condition due to relative resistance to medical treatment and requirement of multiple sessions with modalities like chemical peels and lasers. There is inadequate literature regarding the efficacy and safety of lasers for dermal pigmentation in Indian skin. One hundred and twenty two patients were enrolled and divided into 4 groups: a) Dermal melasma b) Acquired dermal macular hyperpigmentation c) Nevus and d) Tattoo. Sequential combination of various lasers were used with different protocols for 4 different groups like ablative pixel Er:YAG, intense pulse light based technologies, Q-Switched and Alma Hybrid lasers for treatment of dermal pigmentation. A total of 4-10 sessions were conducted at three weekly intervals. Results were evaluated by comparing photographs at baseline, one month after the last session and then at 6 months interval to assess the relapse. All groups showed a statistically significant reduction in pigmentation. The mean treatment duration was 5-7 months for tattoo, lichen planus pigmentosus and melasma with 6-8 number of sessions. The mean treatment duration for nevus was 7-9 months with 8-10 sessions. Lasers are safe and effective modalities in Indian skin type for treatment of dermal pigmentation. Treatment period and relapse of dermal pigmentation may be reduced by combining resurfacing and chromophore selective lasers along with adequate dietary and lifestyle modifications to minimize complications and recurrence rates.

Keywords

Pigmentation; Melasma; Q switch laser; tattoo; birth marks

Subject

Medicine and Pharmacology, Dermatology

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