Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Action of Viscus Album L. on Diabetes and Hypertension in the Veterinary Field

Version 1 : Received: 5 October 2023 / Approved: 5 October 2023 / Online: 5 October 2023 (08:27:01 CEST)

How to cite: Pelini, P. Action of Viscus Album L. on Diabetes and Hypertension in the Veterinary Field. Preprints 2023, 2023100265. https://doi.org/10.20944/preprints202310.0265.v1 Pelini, P. Action of Viscus Album L. on Diabetes and Hypertension in the Veterinary Field. Preprints 2023, 2023100265. https://doi.org/10.20944/preprints202310.0265.v1

Abstract

Viscum album L., also known as “Mistletoe”, is a hemiparasitic plant native to the European continent that grows on various host trees. This plant contains a wide variety of active compounds that can be used for treat various diseases, such as diabetes, hypertension, as an anti- inflammatory and antioxidant. However, it is most indicated in human medicine for the adjuvant treatment of cancer patients. Both for its properties directed against neoplastic cells and for its antioxidant and anti-inflammatory properties. In Veterinary Medicine, I am very few studies are recorded for animals, although formulations are available for commercial use in oral and injectable form, mostly for homeopathic use. Many studies have been conducted on a large scale by groups of independent researchers and doctors in several countries, such as Switzerland, Germany and Brazil. Therefore, this review aimed to collect data on the use of Viscum album in Veterinary Medicine in order to encourage research in this sector not only in oncological diseases but in other directions in which Viscum can find use as an anti-pretensive and anti-diabetic agent. Introduction: Lectins, flavonoids, phenols such as phenylpropanoids, coumarins, sterols, lignans, terpenoids, phenylpropanoids, alkaloids, fatty acids and viscotoxins are among the main active ingredients present in the phytocomplexes of the Viscum album plant. In particular, Attention should be given to specific oligoproteins in consideration of their activity biological [1]. present in The foliage and fruits of V. album, as in other related species, contain low-weight proteins molecular type of thionin, called viscotoxins, as well as characteristic lectins, called viscolectins, both can contribute to its system defense and can be found in extracts and related products. These classes of Viscum microproteins have received considerable attention due to their contribution to effects cytotoxics and immunostimulants of mistletoe extracts used in medicine, as discussed later, including their mechanism of action [ 2–3] viscotoxins can increase the number of cells circulating naturalkillers and consequently improve the response host antitumor immunity [ 8]. Likewise, the a viscotoxin has an effective immunomodulatory impact on human and animal granulocytes [ 9, 10] and also acts on cellular apoptosis [11]. The cytotoxic action of viscotoxin is comparable to that of conventional chemotherapeutic agents [ 12].

Keywords

Viscum album; Paolo Pelini; veterinary medicine; hypertension,diabetes

Subject

Medicine and Pharmacology, Veterinary Medicine

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