Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Image quality and quantitative PET parameters of low-dose [18F]FDG PET in a Total-Body PET/CT scanner.

Eduardo Calderón
ORCID logo ,
Fabian P. Schmidt
,
Wenhong Lan
,
Salvador Castaneda-Vega
ORCID logo ,
Andreas S. Brendlin
ORCID logo ,
Nils F. Trautwein
,
Helmut Dittmann
ORCID logo ,
Christian La Fougère
ORCID logo ,
Lena Sophie Kiefer
* ORCID logo
Version 1 : Received: 2 October 2023 / Approved: 3 October 2023 / Online: 4 October 2023 (07:25:34 CEST)

A peer-reviewed article of this Preprint also exists.

Calderón, E.; Schmidt, F.P.; Lan, W.; Castaneda-Vega, S.; Brendlin, A.S.; Trautwein, N.F.; Dittmann, H.; la Fougère, C.; Kiefer, L.S. Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET/CT Scanner. Diagnostics 2023, 13, 3240. Calderón, E.; Schmidt, F.P.; Lan, W.; Castaneda-Vega, S.; Brendlin, A.S.; Trautwein, N.F.; Dittmann, H.; la Fougère, C.; Kiefer, L.S. Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET/CT Scanner. Diagnostics 2023, 13, 3240.

Abstract

Total-body PET/CT scanners provide increased sensitivity, enabling the adjustment of imaging parameters by reducing injected activity or shortening acquisition time. This study aimed to evaluate the limitations of reduced [18F]FDG activity doses on image quality, lesion detectabil-ity, and quantification of lesion uptake in the Biograph Vision Quadra, as well as to assess the benefits of the recently introduced ultra-high sensitivity mode in a clinical setting. A number of 26 patients who underwent [18F]FDG-PET/CT (3.0 MBq/kg, 5 min. scan time) were included in this analysis. PET raw data was rebinned for shorter frame durations to simulate 5 min. scans with lower activities in high sensitivity (HS) and ultra-high sensitivity (UHS) modes. Image quality, noise, and lesion detectability (n=82) were assessed using a 5-point Likert scale. The co-efficient of variation (CoV), signal-to-noise ratio (SNR), tumor-to-background ratio (TBR), and standardized uptake values (SUV) including SUVmean, SUVmax, and SUVpeak were evaluated. Sub-jective image ratings were generally superior in UHS compared to HS mode. At 0.5 MBq/kg, le-sion detectability decreased to 95% (HS) and 98% (UHS). SNR was comparable at 1.0 MBq/kg in HS (5.7±0.6) and 0.5 MBq/kg in UHS (5.5±0.5). With lower doses, there were negligible reductions in SUVmean and SUVpeak, whereas SUVmax increased steadily. Reducing [18F]FDG activity to 1.0 MBq/kg (HS/UHS) in a total-body PET/CT provides diagnostic image quality without statistical-ly significant changes in uptake parameters. UHS mode improves image quality, noise, and le-sion detectability compared to HS mode.

Keywords

Keywords: Total-Body PET/CT Scanner, LAFOV PET/CT, low-dose [18F]FDG PET, [18F]FDG

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.