Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Image quality and quantitative PET parameters of low-dose [18F]FDG PET in a Total-Body PET/CT scanner.

Eduardo Calderón
ORCID logo ,
Fabian P. Schmidt
,
Wenhong Lan
,
Salvador Castaneda-Vega
ORCID logo ,
Andreas S. Brendlin
ORCID logo ,
Nils F. Trautwein
,
Helmut Dittmann
ORCID logo ,
Christian La Fougère
ORCID logo ,
Lena Sophie Kiefer
* ORCID logo
Version 1 : Received: 2 October 2023 / Approved: 3 October 2023 / Online: 4 October 2023 (07:25:34 CEST)

A peer-reviewed article of this Preprint also exists.

Calderón, E.; Schmidt, F.P.; Lan, W.; Castaneda-Vega, S.; Brendlin, A.S.; Trautwein, N.F.; Dittmann, H.; la Fougère, C.; Kiefer, L.S. Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET/CT Scanner. Diagnostics 2023, 13, 3240. Calderón, E.; Schmidt, F.P.; Lan, W.; Castaneda-Vega, S.; Brendlin, A.S.; Trautwein, N.F.; Dittmann, H.; la Fougère, C.; Kiefer, L.S. Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET/CT Scanner. Diagnostics 2023, 13, 3240.

Abstract

Total-body PET/CT scanners provide increased sensitivity, enabling the adjustment of imaging parameters by reducing injected activity or shortening acquisition time. This study aimed to evaluate the limitations of reduced [18F]FDG activity doses on image quality, lesion detectabil-ity, and quantification of lesion uptake in the Biograph Vision Quadra, as well as to assess the benefits of the recently introduced ultra-high sensitivity mode in a clinical setting. A number of 26 patients who underwent [18F]FDG-PET/CT (3.0 MBq/kg, 5 min. scan time) were included in this analysis. PET raw data was rebinned for shorter frame durations to simulate 5 min. scans with lower activities in high sensitivity (HS) and ultra-high sensitivity (UHS) modes. Image quality, noise, and lesion detectability (n=82) were assessed using a 5-point Likert scale. The co-efficient of variation (CoV), signal-to-noise ratio (SNR), tumor-to-background ratio (TBR), and standardized uptake values (SUV) including SUVmean, SUVmax, and SUVpeak were evaluated. Sub-jective image ratings were generally superior in UHS compared to HS mode. At 0.5 MBq/kg, le-sion detectability decreased to 95% (HS) and 98% (UHS). SNR was comparable at 1.0 MBq/kg in HS (5.7±0.6) and 0.5 MBq/kg in UHS (5.5±0.5). With lower doses, there were negligible reductions in SUVmean and SUVpeak, whereas SUVmax increased steadily. Reducing [18F]FDG activity to 1.0 MBq/kg (HS/UHS) in a total-body PET/CT provides diagnostic image quality without statistical-ly significant changes in uptake parameters. UHS mode improves image quality, noise, and le-sion detectability compared to HS mode.

Keywords

Keywords: Total-Body PET/CT Scanner, LAFOV PET/CT, low-dose [18F]FDG PET, [18F]FDG

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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