Version 1
: Received: 28 September 2023 / Approved: 29 September 2023 / Online: 29 September 2023 (10:36:34 CEST)
How to cite:
Zuniga, J.M.; Evenson, A.; D'Ovidio, A. Effectiveness and Applications of an Antimicrobial Biopolymer Compatible with Additive Manufacturing. Preprints2023, 2023092098. https://doi.org/10.20944/preprints202309.2098.v1
Zuniga, J.M.; Evenson, A.; D'Ovidio, A. Effectiveness and Applications of an Antimicrobial Biopolymer Compatible with Additive Manufacturing. Preprints 2023, 2023092098. https://doi.org/10.20944/preprints202309.2098.v1
Zuniga, J.M.; Evenson, A.; D'Ovidio, A. Effectiveness and Applications of an Antimicrobial Biopolymer Compatible with Additive Manufacturing. Preprints2023, 2023092098. https://doi.org/10.20944/preprints202309.2098.v1
APA Style
Zuniga, J.M., Evenson, A., & D'Ovidio, A. (2023). Effectiveness and Applications of an Antimicrobial Biopolymer Compatible with Additive Manufacturing. Preprints. https://doi.org/10.20944/preprints202309.2098.v1
Chicago/Turabian Style
Zuniga, J.M., Alex Evenson and Andrew D'Ovidio. 2023 "Effectiveness and Applications of an Antimicrobial Biopolymer Compatible with Additive Manufacturing" Preprints. https://doi.org/10.20944/preprints202309.2098.v1
Abstract
Background: Advances in additive manufacturing and the development of antimicrobial biopolymers facilitate the production of critical medical devices with strong and safe biocidal properties. The purpose of this study was to assess the antimicrobial efficacy, safety, and longevity of a polylactic acid-based biopolymer supplemented with a copper-based composite additive. Methods: An antimicrobial polylactic acid-based biopolymer was tested against several inoculants including Staphylococcus Aureus, MRSA, E. coli, Listeria, HCoV-229E (a SARS-CoV-2 surrogate), and HIV-1. Material safety was evaluated according to international testing standards for in vitro cytotoxicity. Results: The main findings of the present investigation showed a strong and long-lasting biocidal effect of a polylactic acid-based biopolymer embedded with a copper-based composite additive against Staphylococcus Aureus, MRSA, E. coli, Listeria, HCoV-229E (a SARS-CoV-2 surrogate), and HIV-1. Furthermore, the cytotoxicity and safety assessment of the antimicrobial biopolymer was found to be “non-toxic” and safe for human skin contact. Conclusions: The present investigation showed that the antimicrobial biopolymer exhibits strong and long-lasting biocidal properties against an array of viral and bacterial inoculants.
Keywords
Additive manufacturing; antimicrobial materials; biopolymers; copper composite additives; medical devices
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
