Version 1
: Received: 26 September 2023 / Approved: 27 September 2023 / Online: 27 September 2023 (10:42:22 CEST)
How to cite:
Jones, R.P.; Ponomarenko, A. Pathogens Have Different Age/Sex Profiles for Hospital Admission and Why COVID-19 Variants Behave as If They Were ‘Different’ Pathogens. Preprints2023, 2023091886. https://doi.org/10.20944/preprints202309.1886.v1
Jones, R.P.; Ponomarenko, A. Pathogens Have Different Age/Sex Profiles for Hospital Admission and Why COVID-19 Variants Behave as If They Were ‘Different’ Pathogens. Preprints 2023, 2023091886. https://doi.org/10.20944/preprints202309.1886.v1
Jones, R.P.; Ponomarenko, A. Pathogens Have Different Age/Sex Profiles for Hospital Admission and Why COVID-19 Variants Behave as If They Were ‘Different’ Pathogens. Preprints2023, 2023091886. https://doi.org/10.20944/preprints202309.1886.v1
APA Style
Jones, R.P., & Ponomarenko, A. (2023). Pathogens Have Different Age/Sex Profiles for Hospital Admission and Why COVID-19 Variants Behave as If They Were ‘Different’ Pathogens. Preprints. https://doi.org/10.20944/preprints202309.1886.v1
Chicago/Turabian Style
Jones, R.P. and Andrey Ponomarenko. 2023 "Pathogens Have Different Age/Sex Profiles for Hospital Admission and Why COVID-19 Variants Behave as If They Were ‘Different’ Pathogens" Preprints. https://doi.org/10.20944/preprints202309.1886.v1
Abstract
A recent study has suggested that the age profiles for deaths due to COVID-19 variants differs between variants and shows male/female specificity. This study demonstrates the age and sex dependency is common among human pathogens. The often-reported higher susceptibility to infections among the young and elderly is true in general but does not apply to individual pathogens. Even among different types of pneumonia there are subtle differences in the age profile. The gender ratio between pathogens likewise shows wide variation from as low as 10% female admissions for leptospirosis to around 90% for gonococcal admissions. The observed age/sex variation observed for mortality due to COVID-19 variants is an expression of a far wider phenomenon with implications to the age/sex response to vaccines. We propose that such differences are likely to be controlled by small noncoding RNAs which act as potent regulators of gene expression leading to altered cell morphology, metabolism, immune function, and response to vaccines.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
