Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury

Dong Keon Yon; Yong Jun Kim; Dong Choon Park; Su Young Jung; Sung Soo Kim; Joon Hyung Yeo; Jeongmin Lee; Jae Min Lee; Seung Geun Yeo

doi:10.20944/preprints202309.1756.v1

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preprints.org > medicine and pharmacology > otolaryngology > doi: 10.20944/preprints202309.1756.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury

Version 1 : Received: 25 September 2023 / Approved: 26 September 2023 / Online: 26 September 2023 (10:30:29 CEST)

How to cite: Yon, D.K.; Kim, Y.J.; Park, D.C.; Jung, S.Y.; Kim, S.S.; Yeo, J.H.; Lee, J.; Lee, J.M.; Yeo, S.G. Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury. Preprints 2023, 2023091756. https://doi.org/10.20944/preprints202309.1756.v1 Yon, D.K.; Kim, Y.J.; Park, D.C.; Jung, S.Y.; Kim, S.S.; Yeo, J.H.; Lee, J.; Lee, J.M.; Yeo, S.G. Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury. Preprints 2023, 2023091756. https://doi.org/10.20944/preprints202309.1756.v1

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MDPI and ACS Style

Yon, D.K.; Kim, Y.J.; Park, D.C.; Jung, S.Y.; Kim, S.S.; Yeo, J.H.; Lee, J.; Lee, J.M.; Yeo, S.G. Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury. Preprints 2023, 2023091756. https://doi.org/10.20944/preprints202309.1756.v1

APA Style

Yon, D.K., Kim, Y.J., Park, D.C., Jung, S.Y., Kim, S.S., Yeo, J.H., Lee, J., Lee, J.M., & Yeo, S.G. (2023). Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury. Preprints. https://doi.org/10.20944/preprints202309.1756.v1

Chicago/Turabian Style

Yon, D.K., Jae Min Lee and Seung Geun Yeo. 2023 "Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury" Preprints. https://doi.org/10.20944/preprints202309.1756.v1

Abstract

Objective: There are currently no known treatment methods for ensuring complete recovery from facial nerve damage. Thus, various basic and clinical studies continue to be conducted to achieve this end. As part of this research, autophagy is being investigated for its role in nerve regeneration. Here, we review the existing literature regarding the involvement and signifi-cance of autophagy in facial nerve injury and regeneration. Methods: A comprehensive litera-ture review was conducted to assess the induction and role of autophagy in facial nerve injury and subsequent regeneration. Results: Studies conducted on rats and mice have demonstrated activation of autophagy and expression of related factors in facial and sciatic nerves. Among the most studied of these factors in relation to degeneration and regeneration of facial and sciatic nerves are LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12. Conclusion: This analysis indicates that autophagy is involved in the process of nerve regeneration follow-ing facial and sciatic nerve damage. Inadequate autophagy induction or failure of autophagy re-sponses can result in regeneration issues after facial or sciatic nerve damage. Animal studies suggest that autophagy plays an important role in facial and sciatic nerve degeneration and re-generation.

Keywords

facial nerve; degeneration; regeneration; autophagy

Subject

Medicine and Pharmacology, Otolaryngology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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