Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chemical Constituents of the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities

Yong Zhang
ORCID logo ,
Chun-Lan Xie
ORCID logo ,
Yuan Wang
,
Xi-Wen He
,
Ming-Min Xie
,
You Li
,
Kai Zhang
,
Zheng-Biao Zou
,
Long-He Yang
* ,
Xian-Wen Yang
* ORCID logo ,
Ren Xu
* ORCID logo
Version 1 : Received: 25 September 2023 / Approved: 25 September 2023 / Online: 25 September 2023 (09:36:29 CEST)

A peer-reviewed article of this Preprint also exists.

Zhang, Y.; Xie, C.-L.; Wang, Y.; He, X.-W.; Xie, M.-M.; Li, Y.; Zhang, K.; Zou, Z.-B.; Yang, L.-H.; Xu, R.; Yang, X.-W. Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities. Mar. Drugs 2023, 21, 538. Zhang, Y.; Xie, C.-L.; Wang, Y.; He, X.-W.; Xie, M.-M.; Li, Y.; Zhang, K.; Zou, Z.-B.; Yang, L.-H.; Xu, R.; Yang, X.-W. Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities. Mar. Drugs 2023, 21, 538.

Abstract

Three new polyketides (penidihydrocitrinins A–C, 1–3) and 14 known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures were elucidated by comprehensive analyses of 1D and 2D NMR, HRESIMS, and ECD calculations. Compounds 1–17 were evaluated for their anti-inflammatory and anti-osteoporotic bioactivities. All isolates exhibited significant inhibitory effects on microglial activation in LPS-stimulated BV-2 cells in a dose-response manner. Notably, compound 14 displayed the strongest effect with the IC50 value of 4.7 µM. Moreover, compounds 6, 7, and 8 not only suppressed osteoclastogenesis, but also promoted osteoblast mineralization.

Keywords

deep-sea; fungus; Penicillium citrinum; polyketides; anti-osteoporosis; anti-inflammation.

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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