Review
Version 1
Preserved in Portico This version is not peer-reviewed
Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma
Version 1
: Received: 22 September 2023 / Approved: 22 September 2023 / Online: 25 September 2023 (09:40:28 CEST)
A peer-reviewed article of this Preprint also exists.
Hsieh, C.-Y.; Lin, C.-C.; Chang, W.-C. Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma. Biomedicines 2023, 11, 2887. Hsieh, C.-Y.; Lin, C.-C.; Chang, W.-C. Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma. Biomedicines 2023, 11, 2887.
Abstract
Taxanes, particularly docetaxel (DTX), has been widely used for combination therapy of head and neck squamous cell carcinoma (HNSCC). For locally advanced unresectable HNSCC, DTX combined with cisplatin and 5-fluorouracil as a revolutionary treatment revealed an advantage in improvement of patient outcome. In addition. DTX plus immune check inhibitors (ICIs) showed low toxicity and increased response of patients with recurrent or metastatic HNSCC (R/M HNSCC). Accumulating data indicate that taxanes not only function as antimitotics but also impair diverse oncogenic signalings including angiogenesis, inflammatory response, ROS production, and apoptosis induction. However, despite an initial response, development of resistance remains a major obstacle to treatment response. Taxane resistance could result from intrinsic mechanisms such as enhanced DNA/RNA damage repair, increased drug efflux, and apoptosis inhibition, and extrinsic effects such as angiogenesis and interactions between tumor cells and immune cells. This review provides an overview of taxanes therapy applied in different stages of HNSCC and describe the mechanisms of taxane resistance in HNSCC. Through a detailed understanding the mechanisms of resistance may help developing the potential therapeutic methods and the effective combination strategies to overcome drug resistance.
Keywords
head and neck squamous cell carcinoma (HNSCC); taxanes; docetaxel (DTX); resistance
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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