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Host Defense Proteins and Peptides with Lipopolysaccharide-Binding Activity from Marine Invertebrates and their Therapeutic Potential in Gram-Negative Sepsis
Solov’eva, T.F.; Bakholdina, S.I.; Naberezhnykh, G.A. Host Defense Proteins and Peptides with Lipopolysaccharide-Binding Activity from Marine Invertebrates and Their Therapeutic Potential in Gram-Negative Sepsis. Mar. Drugs2023, 21, 581.
Solov’eva, T.F.; Bakholdina, S.I.; Naberezhnykh, G.A. Host Defense Proteins and Peptides with Lipopolysaccharide-Binding Activity from Marine Invertebrates and Their Therapeutic Potential in Gram-Negative Sepsis. Mar. Drugs 2023, 21, 581.
Solov’eva, T.F.; Bakholdina, S.I.; Naberezhnykh, G.A. Host Defense Proteins and Peptides with Lipopolysaccharide-Binding Activity from Marine Invertebrates and Their Therapeutic Potential in Gram-Negative Sepsis. Mar. Drugs2023, 21, 581.
Solov’eva, T.F.; Bakholdina, S.I.; Naberezhnykh, G.A. Host Defense Proteins and Peptides with Lipopolysaccharide-Binding Activity from Marine Invertebrates and Their Therapeutic Potential in Gram-Negative Sepsis. Mar. Drugs 2023, 21, 581.
Abstract
Sepsis is a life-threatening complication of an infectious process that results from excessive and uncontrolled activation of the host's pro-inflammatory immune response to a pathogen. Lipopolysaccharide (LPS), also known as endotoxin, which is a major component of the Gram-negative bacteria outer membrane, plays a key role in the development of Gram-negative sepsis and septic shock in humans. To date, no specific and effective drug against sepsis has been developed. This review summarizes data on LPS-binding proteins from marine invertebrates (ILBPs), that inhibit LPS toxic effects, and are of interest as potential drugs for the sepsis treatment. The structure, physicochemical properties, antimicrobial and LPS-binding/neutralizing activity of these proteins and their synthetic analogues are considered in details. Problems that arise during clinical trials of potential anti-endotoxic drugs are discussed.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
