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An EPR Spectroscopy Study of NO and Copper Content in Injured and Uninjured Areas of the Brain After a Combined Injury of the Brain and Spinal Cord in Rats
Andrianov, V.V.; Kulchitsky, V.A.; Yafarova, G.G.; Bazan, L.V.; Bogodvid, T.K.; Deryabina, I.B.; Muranova, L.N.; Silantyeva, D.I.; Arslanov, A.I.; Paveliev, M.N.; Fedorova, E.V.; Filipovich, T.A.; Nagibov, A.V.; Gainutdinov, K.L. Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury. Molecules2023, 28, 7359.
Andrianov, V.V.; Kulchitsky, V.A.; Yafarova, G.G.; Bazan, L.V.; Bogodvid, T.K.; Deryabina, I.B.; Muranova, L.N.; Silantyeva, D.I.; Arslanov, A.I.; Paveliev, M.N.; Fedorova, E.V.; Filipovich, T.A.; Nagibov, A.V.; Gainutdinov, K.L. Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury. Molecules 2023, 28, 7359.
Andrianov, V.V.; Kulchitsky, V.A.; Yafarova, G.G.; Bazan, L.V.; Bogodvid, T.K.; Deryabina, I.B.; Muranova, L.N.; Silantyeva, D.I.; Arslanov, A.I.; Paveliev, M.N.; Fedorova, E.V.; Filipovich, T.A.; Nagibov, A.V.; Gainutdinov, K.L. Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury. Molecules2023, 28, 7359.
Andrianov, V.V.; Kulchitsky, V.A.; Yafarova, G.G.; Bazan, L.V.; Bogodvid, T.K.; Deryabina, I.B.; Muranova, L.N.; Silantyeva, D.I.; Arslanov, A.I.; Paveliev, M.N.; Fedorova, E.V.; Filipovich, T.A.; Nagibov, A.V.; Gainutdinov, K.L. Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury. Molecules 2023, 28, 7359.
Abstract
Here we performed a comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and copper content in the injured and uninjured areas of the frontal lobes and the hippocampus of the brain of male Wistar rats, after modeling of combined brain and spinal cord injury. Brain and spinal cord injury were modelled by local destruction of the left precentral region of the brain using a stylet followed by hemorrhage injury at the level of the first lumbar vertebra of the spinal cord. We found a significant decrease in NO production 7 days after injury modeling in the injured and uninjured (contralateral) brain regions, but the copper content remained unchanged one week after injury modeling. Thus, combined brain and spinal cord injury is not accompanied by a radical change in the activity of the antioxidant system in the brain, which is also confirmed by the absence of changes in NO production and copper content in the hippocampus.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
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