Vaz, L.M.; Branco, R.; Morais, P.V.; Guiomar, A.J. Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings. Membranes2023, 13, 877.
Vaz, L.M.; Branco, R.; Morais, P.V.; Guiomar, A.J. Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings. Membranes 2023, 13, 877.
Vaz, L.M.; Branco, R.; Morais, P.V.; Guiomar, A.J. Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings. Membranes2023, 13, 877.
Vaz, L.M.; Branco, R.; Morais, P.V.; Guiomar, A.J. Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings. Membranes 2023, 13, 877.
Abstract
Wound infection is a common complication of chronic wounds. It can impair healing, which may not occur without external help. Antimicrobial dressings (AMDs) are a type of external help to infected chronic wounds. In this study, highly porous membranes made of only chitosan and containing the antiseptic polyhexanide (poly(hexamethylene biguanide); PHMB) were prepared by cryogelation, aiming to be used in AMDs. These membranes exhibited high water swelling capacity, fast water absorption and high water vapor transmission. The best drug loading method involved simultaneous loading by soaking in a PHMB solution and sterilization by autoclaving, resulting in sterilized, drug-loaded membranes. The drug release kinetics was comparable to that of a commercial PHMB-releasing AMD assayed under the same conditions. These membranes exhibited high antibacterial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, which are bacterial species commonly found in infected wounds, and blood clotting activity. The obtained results suggest that these membranes may be suitable for use in the development of AMDs.
Keywords
polyhexanide; poly(hexamethylene biguanide); polyhexamethylene biguanide; PHMB; chitosan; membrane; controlled drug release; drug delivery; wound dressing; antimicrobial
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
