PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus
Version 1
: Received: 19 September 2023 / Approved: 20 September 2023 / Online: 21 September 2023 (04:29:15 CEST)
How to cite:
Sagdic, T.; Aktas, G. Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Preprints2023, 2023091394. https://doi.org/10.20944/preprints202309.1394.v1
Sagdic, T.; Aktas, G. Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Preprints 2023, 2023091394. https://doi.org/10.20944/preprints202309.1394.v1
Sagdic, T.; Aktas, G. Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Preprints2023, 2023091394. https://doi.org/10.20944/preprints202309.1394.v1
APA Style
Sagdic, T., & Aktas, G. (2023). Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202309.1394.v1
Chicago/Turabian Style
Sagdic, T. and Gulali Aktas. 2023 "Evaluation of the Relationship between CRP/Lymphocyte Ratio and Blood Sugar Regulation and Other Metabolic Parameters in Patients with Type 2 Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202309.1394.v1
Abstract
C-reactive protein to lymphocyte ratio (CLR) has been shown to be associated with diseases characterized by chronic, low-grade inflammation. Since type 2 diabetes (T2DM) is also associated with inflammation, we aimed to study the association between CLR and T2DM. Patients with T2DM who presented to internal medicine outpatient clinics of our institution were divided into 2 groups according to their glycosylated hemoglobin (HbA1c) levels as well-controlled (HbA1c<7%) and poorly controlled (HbA1c≥7%) T2DM groups. Subjects assigned as healthy in routine check-up were included as control group. CLR values of the well and poorly controlled diabetics and control cases were compared. CLR of T2DM group (3.51 (0.03-21.78)) was significantly higher than that of the controls (0.65 (0.02-2.92)) (p<0.001). CLR was found to have a sensitivity of 63.2% and a specificity of 97.3% in predicting T2DM. The CLR value of patients with poor diabetic control was 4.76 (0.06-21.78), while the CLR value of patients with well controlled disease was 2.53 (0.03-12.07) (p<0.001). The sensitivity and specificity of the CLR in demonstrating poor diabetic control was 41.2% and the 86.1%, respectively. In conclusion, elevated CLR in T2DM patients and even more increased levels in poorly controlled diabetics suggest that CLR could be a useful additional diagnostic tool in treatment follow-up of the T2DM population.
Keywords
type 2 diabetes mellitus (T2DM); c-reactive protein (CRP); CRP/lymphocytes (CLR); inflammation; biomarker
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
