Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Conduction System Pacing for Cardiac Resynchronization Therapy

Óscar Cano
* ORCID logo ,
Javier Navarrete
,
Pablo Jover
,
Joaquín Osca
,
Maite Izquierdo
,
Josep Navarro
,
Hebert David Ayala
,
Luis Martínez-Dolz
Version 1 : Received: 18 September 2023 / Approved: 19 September 2023 / Online: 19 September 2023 (07:11:41 CEST)

A peer-reviewed article of this Preprint also exists.

Cano, Ó.; Navarrete-Navarro, J.; Jover, P.; Osca, J.; Izquierdo, M.; Navarro, J.; Ayala, H.D.; Martínez-Dolz, L. Conduction System Pacing for Cardiac Resynchronization Therapy. J. Cardiovasc. Dev. Dis. 2023, 10, 448. Cano, Ó.; Navarrete-Navarro, J.; Jover, P.; Osca, J.; Izquierdo, M.; Navarro, J.; Ayala, H.D.; Martínez-Dolz, L. Conduction System Pacing for Cardiac Resynchronization Therapy. J. Cardiovasc. Dev. Dis. 2023, 10, 448.

Abstract

Cardiac resynchronization therapy (CRT) via biventricular pacing (BiVP-CRT) is considered a mainstay treatment for symptomatic heart failure patients with reduced ejection fraction and wide QRS. However, up to one third of patients receiving BiVP-CRT are considered non-responders to the therapy. Multiples strategies have been proposed to maximize the percentage of CRT responders including two new physiological pacing modalities that have emerged during the lasts years: His bundle pacing (HBP) and left bundle branch area pacing (LBBAP). Both pacing techniques aim at restoring the normal electrical activation of the ventricles through the native conduction system in opposition to the cell-to-cell activation of conventional right ventricular myocardial pacing. Conduction system pacing (CSP), including both HBP and LBBAP appears to be a promising pacing modality for delivering CRT and has proven to be safe and feasible in this particular setting. This article will review the current state of the art of CSP-based CRT, its limitations and future directions.

Keywords

cardiac resynchronization therapy; His bundle pacing; Left bundle branch area pacing; conduction system pacing

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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