Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association of Blood Leukocytes and Hemoglobin with Hospital Mortality in Acute Pulmonary Embolism

Slobodan Obradovic
,
Dzudovic Boris
* ORCID logo ,
Bojana Subotic
,
Sonja Šalinger
,
Jovan Matijašević
,
Marija Benic
,
Tamara Kovačević Preradović
ORCID logo ,
Ana Kovacevic-Kuzmanovic
,
Irena Mitevska
ORCID logo ,
Vladimir Miloradovic
,
Ema Jevtic
,
Aleksandar Neskovic
Version 1 : Received: 26 August 2023 / Approved: 30 August 2023 / Online: 30 August 2023 (11:02:52 CEST)

A peer-reviewed article of this Preprint also exists.

Obradovic, S.; Dzudovic, B.; Subotic, B.; Salinger, S.; Matijasevic, J.; Benic, M.; Kovacevic, T.; Kovacevic-Kuzmanovic, A.; Mitevska, I.; Miloradovic, V.; Jevtic, E.; Neskovic, A. Association of Blood Leukocytes and Hemoglobin with Hospital Mortality in Acute Pulmonary Embolism. J. Clin. Med. 2023, 12, 6269. Obradovic, S.; Dzudovic, B.; Subotic, B.; Salinger, S.; Matijasevic, J.; Benic, M.; Kovacevic, T.; Kovacevic-Kuzmanovic, A.; Mitevska, I.; Miloradovic, V.; Jevtic, E.; Neskovic, A. Association of Blood Leukocytes and Hemoglobin with Hospital Mortality in Acute Pulmonary Embolism. J. Clin. Med. 2023, 12, 6269.

Abstract

This study aimed to assess the prognostic significance of total leukocyte count (TLC) and hemoglobin (Hb) levels upon admission for patients with acute pulmonary embolism (PE), considering the European Society of Cardiology (ESC) model for mortality risk. 1622 patients from a regional PE registry were included. Decision tree statistics were employed to evaluate TLC and Hb's prognostic value, both independently and in conjunction with the ESC model. Results indicated all-cause and PE-related in-hospital mortality rates of 10.7% and 6.5% respectively. Subgrouping patients based on TLC cutoff values (≤11.2, 11.2-16.84, >16.84 x10^9/L) revealed increasing all-cause mortality risks (7.0%, 11.8%, 30.2%). Incorporating Hb levels (≤126 g/L or above) further stratified the lowest risk group into two strata with all-cause mortality rates of 10.1% and 4.7%. Similar trends were observed for PE-related mortality. Notably, TLC improved risk assessment for intermediate-high risk patients within the ESC model, while Hb levels enhanced mortality risk stratification for lower risk PE patients in the ESC model for all-cause mortality. In conclusion, TLC and Hb levels upon admission can refine the ESC model's mortality risk classification for patients with acute PE, providing valuable insights for improved patient management.

Keywords

pulmonary embolism; mortality; total leukocyte counts; hemoglobin

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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