Version 1
: Received: 23 August 2023 / Approved: 23 August 2023 / Online: 24 August 2023 (08:20:32 CEST)
How to cite:
Cristiano, V.B.; Szortyka, M.F.; Belmonte-de-Abreu, P.S. Effect of Assisted Physical Exercise over Inflammatory Markers and Lactate in Schizophrenia—A Controlled Trial. Preprints2023, 2023081686. https://doi.org/10.20944/preprints202308.1686.v1
Cristiano, V.B.; Szortyka, M.F.; Belmonte-de-Abreu, P.S. Effect of Assisted Physical Exercise over Inflammatory Markers and Lactate in Schizophrenia—A Controlled Trial. Preprints 2023, 2023081686. https://doi.org/10.20944/preprints202308.1686.v1
Cristiano, V.B.; Szortyka, M.F.; Belmonte-de-Abreu, P.S. Effect of Assisted Physical Exercise over Inflammatory Markers and Lactate in Schizophrenia—A Controlled Trial. Preprints2023, 2023081686. https://doi.org/10.20944/preprints202308.1686.v1
APA Style
Cristiano, V.B., Szortyka, M.F., & Belmonte-de-Abreu, P.S. (2023). Effect of Assisted Physical Exercise over Inflammatory Markers and Lactate in Schizophrenia—A Controlled Trial. Preprints. https://doi.org/10.20944/preprints202308.1686.v1
Chicago/Turabian Style
Cristiano, V.B., Michele Fonseca Szortyka and Paulo Silva Belmonte-de-Abreu. 2023 "Effect of Assisted Physical Exercise over Inflammatory Markers and Lactate in Schizophrenia—A Controlled Trial" Preprints. https://doi.org/10.20944/preprints202308.1686.v1
Abstract
Background: Schizophrenia is a mental disorder associated with inflammatory and oxidative stress markers such as lactate; in addition, the rate of physical inactivity in this population is very high, which leads to physical and metabolic alterations.
Aims: This study measured the effect of assisted physical exercise over lactate levels in schizophrenia.
Methods: Stable outpatients with schizophrenia and a group of Healthy controls received two different programs of Physical exercise (Aerobic and Functional) in a clinical trial.
Results: Patients had higher lactate compared to healthy controls before and after intervention, and had higher rate of lactate increase after activity. The finding of increased lactate in schizophrenia detected before and after physical exercise deserve further attention in biomarker studies and in the development of physical rehabilitation in schizophrenia, suggesting different profile of oxidative metabolism after physical exercise. Basal increased lactate may reflect mitochondrial dysfunction or metabolic dysregulation, and the higher rate of increase may reflect a different metabolic and oxidative process.
Conclusion: The finding is in line with recent studies as surrogate of mitochondrial dysfunction in schizophrenia and points to the need of additional studies on mitochondrial activity in schizophrenia, and to additional care in the design of physical interventions in schizophrenia.
Keywords
Schizophrenia; Lactate; Physical exercise; Creatine Kinase (CK); C-Reactive Protein (CRP)
Subject
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
