Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Manifestation of Pancytopenia Associated with COVID-19 as Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia (AA)

Version 1 : Received: 21 August 2023 / Approved: 22 August 2023 / Online: 22 August 2023 (13:19:19 CEST)

How to cite: Aguilar, J.J.; Dhillon, V.; Balasubramanian, S. Manifestation of Pancytopenia Associated with COVID-19 as Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia (AA). Preprints 2023, 2023081585. https://doi.org/10.20944/preprints202308.1585.v1 Aguilar, J.J.; Dhillon, V.; Balasubramanian, S. Manifestation of Pancytopenia Associated with COVID-19 as Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia (AA). Preprints 2023, 2023081585. https://doi.org/10.20944/preprints202308.1585.v1

Abstract

We report two cases of pancytopenia in patients after recovering from a mild COVID-19, now presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. These cases il-lustrate a common pathway whereby a viral trigger causes clonal expansion of a hematological disorder. Although the association in both cases are temporal, and that COVID-19 may be an in-cidental diagnosis, the growing evidence related to hematological effects of SARS-CoV-2 infec-tion highlights the need for further investigation into the hematological consequences of COVID-19, particularly in the post-pandemic era.

Keywords

Paroxysmal nocturnal hemoglobinuria; aplastic anemia; SARS-CoV-2

Subject

Medicine and Pharmacology, Hematology

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