Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Anti-Cancer and Anti-Diabetics Potentials of Punicalagin Derivatives Extracted from Peeled of Pomegranate (Punica granatum)

Sabina Yasmin
,
Ajay Kumar Yadav
,
Rosolonjatovo Heriniavo Michael
,
Shabana Khatun
,
Sarthak Chauhan
,
Manoj Kurmi
,
Simranjit Kaur
,
Nazima Haider
,
Ajay Kumar Sah
,
Akash Kumar
,
Sumeet Gupta
ORCID logo ,
Pritam Singh
,
Kavita Munjal
* ,
Mohammad Yousuf Ansari
* ORCID logo
Version 1 : Received: 17 August 2023 / Approved: 22 August 2023 / Online: 22 August 2023 (10:10:52 CEST)

How to cite: Yasmin, S.; Yadav, A.K.; Michael, R.H.; Khatun, S.; Chauhan, S.; Kurmi, M.; Kaur, S.; Haider, N.; Sah, A.K.; Kumar, A.; Gupta, S.; Singh, P.; Munjal, K.; Ansari, M.Y. Anti-Cancer and Anti-Diabetics Potentials of Punicalagin Derivatives Extracted from Peeled of Pomegranate (Punica granatum). Preprints 2023, 2023081553. https://doi.org/10.20944/preprints202308.1553.v1 Yasmin, S.; Yadav, A.K.; Michael, R.H.; Khatun, S.; Chauhan, S.; Kurmi, M.; Kaur, S.; Haider, N.; Sah, A.K.; Kumar, A.; Gupta, S.; Singh, P.; Munjal, K.; Ansari, M.Y. Anti-Cancer and Anti-Diabetics Potentials of Punicalagin Derivatives Extracted from Peeled of Pomegranate (Punica granatum). Preprints 2023, 2023081553. https://doi.org/10.20944/preprints202308.1553.v1

Abstract

Abstract: A punicalagin is a metabolic product of pomegranate fruits and peeled. We have compiled the recent literature review from different sources. The extract of pomegranate fruits and peel has been reported for health-beneficial properties in inflammation-associated chronic disease and the regulatory role in NF-KB, MAPK, IL-6/JAK/STAT3, and PI3K/AKT/mTOR signaling pathway. Punicalagin is an ellagitannin found in the peel of pomegranate (Punica granatum). It is a polyphenol with proven biological/pharmacological activities like antioxidant, hepatoprotective, an-ti-atherosclerotic, anti-cancer, anti-neurological, anti-diabetic, and anti-digestive. The extracts have a rich source of hydrolyzable tannin and anthocyanin exhibiting strong anti-neoplastic properties. Anti-cancer activities of pomegranate with reference to modulated signaling pathways in various cancer diseases have been recently reported. The punicalagin-induced redirection of the signal-transduction pathway from survival and proliferation into the cell cycle by arrested the living cells. Apoptosis senescence and autophagy and thus compromising neoplastic progression are delineated. This review is based mainly on data obtained from various sources including the in-vitro cell line model and its activities that are concerned with the effect of punicalagin activities on various cell types.

Keywords

Punicalagin; hepatoprotective; polyphenols

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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