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The Possible Role of Anti- and Pro-Tumour-Infiltrating Lymphocytes on Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy
Geršak, K.; Geršak, B.M.; Gazić, B.; Klevišar Ivančič, A.; Drev, P.; Ružić Gorenjec, N.; Grašič Kuhar, C. The Possible Role of Anti- and Protumor-Infiltrating Lymphocytes in Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy. Cancers2023, 15, 4794.
Geršak, K.; Geršak, B.M.; Gazić, B.; Klevišar Ivančič, A.; Drev, P.; Ružić Gorenjec, N.; Grašič Kuhar, C. The Possible Role of Anti- and Protumor-Infiltrating Lymphocytes in Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy. Cancers 2023, 15, 4794.
Geršak, K.; Geršak, B.M.; Gazić, B.; Klevišar Ivančič, A.; Drev, P.; Ružić Gorenjec, N.; Grašič Kuhar, C. The Possible Role of Anti- and Protumor-Infiltrating Lymphocytes in Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy. Cancers2023, 15, 4794.
Geršak, K.; Geršak, B.M.; Gazić, B.; Klevišar Ivančič, A.; Drev, P.; Ružić Gorenjec, N.; Grašič Kuhar, C. The Possible Role of Anti- and Protumor-Infiltrating Lymphocytes in Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy. Cancers 2023, 15, 4794.
Abstract
Tumour microenvironment, composed of pro- and anti-tumour immune cells, affects cancer cells behaviour. We aimed to evaluate if tumour-infiltrating lymphocyte (TIL) density and TILs subtypes in core biopsies at diagnosis of breast cancer patients could predict pathologic complete response (pCR; ypT0/is ypN0) from neoadjuvant systemic therapy (NST). The TIL subtypes were determined based on the proportions of presumably anti-tumour (CD8+, CXCL13+) and pro-tumour (PD-1+, FOXP3+) immune cells. A prospective, non-interventional study including 171 participants undergoing NST was performed. The median TIL density for the entire cohort was 10% (IQR: 3.5-23.8), and 59 (35%) patients achieved pCR. TIL density was positively associated with pCR (univariately and multivariably). In the multivariable logistic regression model, TIL density was an independent predictor of pCR (p=0.012, OR 1.27; 95% CI 1.05-1.54) when controlled for age (p=0.232), Ki-67 (p=0.001), node-negative status (p=0.024), and HER2+/triple negative vs luminal B-like subtype (p<0.001). In our sample, higher proportions of PD-1+ TILs and FOXP3+ TILs were associated with a higher probability of pCR but the association was not statistically significant. In the exploratory multivariable analysis, we showed that only higher CD8+ TILs were associated with pCR. In conclusion, TIL density and its subtypes are associated with pCR.
Medicine and Pharmacology, Oncology and Oncogenics
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