Version 1
: Received: 14 August 2023 / Approved: 15 August 2023 / Online: 15 August 2023 (08:08:24 CEST)
How to cite:
Gatseva, P.R.; Blazhev, A.; Yordanov, Z.; Atanasova, V. Early Diagnostic Markers of Late-Onset Sepsis of the Newborn. Preprints2023, 2023081095. https://doi.org/10.20944/preprints202308.1095.v1
Gatseva, P.R.; Blazhev, A.; Yordanov, Z.; Atanasova, V. Early Diagnostic Markers of Late-Onset Sepsis of the Newborn. Preprints 2023, 2023081095. https://doi.org/10.20944/preprints202308.1095.v1
Gatseva, P.R.; Blazhev, A.; Yordanov, Z.; Atanasova, V. Early Diagnostic Markers of Late-Onset Sepsis of the Newborn. Preprints2023, 2023081095. https://doi.org/10.20944/preprints202308.1095.v1
APA Style
Gatseva, P.R., Blazhev, A., Yordanov, Z., & Atanasova, V. (2023). Early Diagnostic Markers of Late-Onset Sepsis of the Newborn. Preprints. https://doi.org/10.20944/preprints202308.1095.v1
Chicago/Turabian Style
Gatseva, P.R., Zarko Yordanov and Victoria Atanasova. 2023 "Early Diagnostic Markers of Late-Onset Sepsis of the Newborn" Preprints. https://doi.org/10.20944/preprints202308.1095.v1
Abstract
The aim of this study was to determine the potential of early inflammatory markers to diagnose late-onset neonatal sepsis - procalcitonin (PCT), interleukin 6 (IL-6), interleukin 8 (IL-8) and endocan (ESM-1), and to compare them with routinely used markers. A prospective (January, 2022 – January, 2023) clinical-epidemiological study was conducted in a third level NICU in Pleven, Bulgaria. Patients with suspected nosocomial infection and healthy controls were tested. A sandwich ELISA method was used to measure the serum concentrations. Sixty newborns with an average gestational age of 29.75 ± 3.61 gestational weeks were included, of which 35 % were symptomatic and infected, 33.3 % were symptomatic but uninfected, and 31.7 % were asymptomatic controls. The mean values of PCT, IL-6, I:T index and PLT differ significantly in the three groups. For ESM-1, IL-8 and CRP, the difference was statistically insignificant. The best sensitivity (78%) and negative predictive value (84%) was found for IL-6. The combination of PCT + IL-6 + I:T+ PLT demonstrated high precision (78%) and best sensitivity (94%) and negative predictive value (95%). The introduction into routine practice of indicators such as PCT and IL-6 may provide an opportunity to promptly optimize the diagnostic and therapeutic approach to LOS.
Keywords
neonates; late-onset sepsis; inflammatory markers
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
