Tissue Metalloproteinases as Crohn Disease Recurrence Markers

Grzegorz Pasternak; Grzegorz Chrzanowski; David Aebisher; Angelika Mysliwiec; Klaudia Dynarowicz; Dorota Bartusik-Aebisher; Rafał Filip

doi:10.20944/preprints202308.0624.v1

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preprints.org > medicine and pharmacology > gastroenterology and hepatology > doi: 10.20944/preprints202308.0624.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Tissue Metalloproteinases as Crohn Disease Recurrence Markers

^* ,

Dorota Bartusik-Aebisher

Rafał Filip

Version 1 : Received: 6 August 2023 / Approved: 7 August 2023 / Online: 8 August 2023 (07:12:46 CEST)

How to cite: Pasternak, G.; Chrzanowski, G.; Aebisher, D.; Mysliwiec, A.; Dynarowicz, K.; Bartusik-Aebisher, D.; Filip, R. Tissue Metalloproteinases as Crohn Disease Recurrence Markers. Preprints 2023, 2023080624. https://doi.org/10.20944/preprints202308.0624.v1 Pasternak, G.; Chrzanowski, G.; Aebisher, D.; Mysliwiec, A.; Dynarowicz, K.; Bartusik-Aebisher, D.; Filip, R. Tissue Metalloproteinases as Crohn Disease Recurrence Markers. Preprints 2023, 2023080624. https://doi.org/10.20944/preprints202308.0624.v1

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MDPI and ACS Style

Pasternak, G.; Chrzanowski, G.; Aebisher, D.; Mysliwiec, A.; Dynarowicz, K.; Bartusik-Aebisher, D.; Filip, R. Tissue Metalloproteinases as Crohn Disease Recurrence Markers. Preprints 2023, 2023080624. https://doi.org/10.20944/preprints202308.0624.v1

APA Style

Pasternak, G., Chrzanowski, G., Aebisher, D., Mysliwiec, A., Dynarowicz, K., Bartusik-Aebisher, D., & Filip, R. (2023). Tissue Metalloproteinases as Crohn Disease Recurrence Markers. Preprints. https://doi.org/10.20944/preprints202308.0624.v1

Chicago/Turabian Style

Pasternak, G., Dorota Bartusik-Aebisher and Rafał Filip. 2023 "Tissue Metalloproteinases as Crohn Disease Recurrence Markers" Preprints. https://doi.org/10.20944/preprints202308.0624.v1

Abstract

Crohn's disease is a non-specific inflammatory bowel disease, which is a chronic condition that affects the ileum and/or large intestine. At the same time, it can also involve any other part of the human body, that is, from the mouth to the anus. The symptoms are very bothersome and cause a significant reduction in quality of life and sometimes even crippling permanent damage to the gastrointestinal tract, which requires enteral or parenteral nutrition for life. The purpose of this study was to investigate tissue metalloproteinases as markers of recurrent Crohn's disease. The experimental groups included 31 patients and 10 patients with normal Crohn's disease, ranging in age from 23-70 years, with a mean age of 40.4. Collected tissues were frozen and then fragmented tissues were homogenized with Ripa Lysis buffer on ice. The supernatant was collared and four metalloproteinases - MMP 3, MMP 7, MMP 8 and MMP 9 - were an-alized by Enzyme-linked Immunosorbent Assay using SEA101HU, SEA102Hu, SEA103Hu and SEA553Hu kits (Cloud-Clone Corp., Kata, TX, USA). All chemical analyses were performed in triplicate. Metalloproteinase content was expressed as mean ± standard deviation. Metalloproteinase 3 and metalloproteinase 8) significantly influenced the possibility of Crohn recurrence

Keywords

Crohn’s disease; metalloproteinases; MMP-3; MMP-8

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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