Cammarota, A.L.; Falco, A.; Basile, A.; Molino, C.; Chetta, M.; D’Angelo, G.; Marzullo, L.; De Marco, M.; Turco, M.C.; Rosati, A. Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment. Cancers2023, 15, 4825.
Cammarota, A.L.; Falco, A.; Basile, A.; Molino, C.; Chetta, M.; D’Angelo, G.; Marzullo, L.; De Marco, M.; Turco, M.C.; Rosati, A. Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment. Cancers 2023, 15, 4825.
Cammarota, A.L.; Falco, A.; Basile, A.; Molino, C.; Chetta, M.; D’Angelo, G.; Marzullo, L.; De Marco, M.; Turco, M.C.; Rosati, A. Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment. Cancers2023, 15, 4825.
Cammarota, A.L.; Falco, A.; Basile, A.; Molino, C.; Chetta, M.; D’Angelo, G.; Marzullo, L.; De Marco, M.; Turco, M.C.; Rosati, A. Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment. Cancers 2023, 15, 4825.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a ravaging disease whose poor prognosis requires a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggested to rather focus on the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer secreted proteins in the complex TME tumor-stroma crosstalk, to sched lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.
Medicine and Pharmacology, Medicine and Pharmacology
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