Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Polyphenols Analysis by LC-MS-ESI and Potent Antioxidant, Anti-Inflammatory, Antimicrobial Activities of Jatropha multifida L. Extracts Used in Benin Pharmacopoeia

Durand Dah-Nouvlessounon
ORCID logo ,
Michaelle Chokki
ORCID logo ,
Essé A Agossou
,
Jean-Baptiste Houédanou
,
Martial Nounagnon
,
Haziz Sina
,
Romana Vulturar
ORCID logo ,
Simona Codruta Heghes
ORCID logo ,
Angela Cozma
,
Jacques François Mavoungou
,
Adriana Fodor
ORCID logo ,
Farid Baba-Moussa
,
Ramona Suharoschi
* ORCID logo ,
Lamine Baba-Moussa
* ORCID logo
Version 1 : Received: 26 July 2023 / Approved: 3 August 2023 / Online: 4 August 2023 (07:41:44 CEST)

A peer-reviewed article of this Preprint also exists.

Dah-Nouvlessounon, D.; Chokki, M.; Agossou, E.A.; Houédanou, J.-B.; Nounagnon, M.; Sina, H.; Vulturar, R.; Heghes, S.C.; Cozma, A.; Mavoungou, J.F.; Fodor, A.; Baba-Moussa, F.; Suharoschi, R.; Baba-Moussa, L. Polyphenol Analysis via LC-MS-ESI and Potent Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Jatropha multifida L. Extracts Used in Benin Pharmacopoeia. Life 2023, 13, 1898. Dah-Nouvlessounon, D.; Chokki, M.; Agossou, E.A.; Houédanou, J.-B.; Nounagnon, M.; Sina, H.; Vulturar, R.; Heghes, S.C.; Cozma, A.; Mavoungou, J.F.; Fodor, A.; Baba-Moussa, F.; Suharoschi, R.; Baba-Moussa, L. Polyphenol Analysis via LC-MS-ESI and Potent Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Jatropha multifida L. Extracts Used in Benin Pharmacopoeia. Life 2023, 13, 1898.

Abstract

Jatropha multifida L. is a plant belong to Euphorbiaceae family used in Benin pharmacopoeia because of its medicinal properties. The objective of this work is to appreciate the therapeutic power of this plant through the evaluation of some of its biological activities. After the preliminary phytochemistry, the polyphenols and flavonoids were quantified and identified by the LC-MS-ESI. The antimicrobial power of the extracts was investigated by agar medium diffusion. The antioxidant power of the extracts was evaluated by the reduction of the DPPH radical, the ABTS radical cation, the feric ion (FRAP) and the lipid peroxidation (LPO). Anti-inflammatory activity was assessed by inhibition of protein (albumin) denaturation. Indeed, different phenolic and flavonoid compounds namely, 2-Hydroxybenzoic acid, o-Coumaroylquinic acid, Apigenin-apiosyl-glucoside, Luteolin-galactoside, Luteolin-glucoside, Luteolin-rhamnoside, Quercetin-glucoside, Quercetin-arabinoside, Dicaffeoyquinic acid, Kaempferol-rhamnoside were identify. The J. mutifida extracts has a bactericidal effect with reference strains of wich CMBs vary from 22.67 mg/ml (S. aureus, S. enteridis, L. monocytogenes and C. albicans) to 47.61 mg/ml (E. coli) and with the meat isolated strains (S. equorum, S. saprophiticus, S. haemoliticus, S. cohnii and S. lentus). Ethanolic extract show the highest DPPH radical scavenging activity (IC50 = 0.72±0.03 mg/ml) while methanolic extract showed the highest ferric ion reduction (46.23±1.10 µgEAA/g). Contrary to the FRAP method, the reducing power with ABTS method of water-ethanolic extract was greater (0.49±0.11 mol ET/g). The same extract show the highest albumin denaturation inhibition power (97.31±0.35%) at 1000µg/ml. J. multifida extracts are rich in bioactive compound with good biological activity

Keywords

Plant extract; LC-MS-ESI; Bioactif compound; Biological activities; Benin

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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