Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Atherogenic Dyslipidemia in Wistar Rats: Study of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench., Euterpe oleracea Martius., Bixa orellana Linné and Chronic SM®

Priscila Faimann Sales
ORCID logo ,
ALINE LOPES DO NASCIMENTO
,
Fernanda Cavalcante Pinheiro
,
Andressa Ketelem Meireles Alberto
,
Abrahão Victor Tavares de Lima Teixeira dos Santos
ORCID logo ,
Helison de oliveira Carvalho
,
Gisele Custódio De Souza
,
And José Carlos Tavares Carvalho
* ORCID logo
Version 1 : Received: 19 July 2023 / Approved: 19 July 2023 / Online: 20 July 2023 (03:20:38 CEST)

A peer-reviewed article of this Preprint also exists.

Sales, P.F.; Nascimento, A.L.; Pinheiro, F.C.; Alberto, A.K.M.; Teixeira dos Santos, A.V.T.L.; Carvalho, H.O.; de Souza, G.C.; Carvalho, J.C.T. Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats. Molecules 2023, 28, 6689. Sales, P.F.; Nascimento, A.L.; Pinheiro, F.C.; Alberto, A.K.M.; Teixeira dos Santos, A.V.T.L.; Carvalho, H.O.; de Souza, G.C.; Carvalho, J.C.T. Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats. Molecules 2023, 28, 6689.

Abstract

Dyslipidemia presents high levels of serum cholesterol, being characterized as a risk factor for cardiovascular diseases, especially for the development of atherosclerosis. E. oleracea (OFEO), A. esculentus (OFAE), B. orellana (OFBO) and granulated (CHR) oils are rich in bioactive compounds with potential to treat changes in lipid metabolism. This study investigated the effects of treatments with oils from A. esculentus, E. oleracea, B. orellana and granules (Chronic SM®) on saturated fat-induced dyslipidemia Cocos nucifera L. The chromatographic profile showed the majority of unsaturated fatty acids in the tested oils. The quantification of tocotrienols and geranylgeraniol was obtained in OFBO and CHR. Treatments with OFEO, OFAE, OFBO and CHR were able to significantly reduce glycemia with p>0.001, as well as hypertriglyceridemia, total cholesterol and LDL-cholesterol, in addition to increasing HDL-cholesterol. The treatments inhibited the formation of atheromatous plaques in the vascular endothelium of the treated rats. The obtained results suggest that the OFEO, OFAE, OFBO and CHR groups have antidyslipidemic effects and antiatherogenic activity.

Keywords

Hypercholesterolemia; Atherosclerosis; vegetable oils

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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