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Cuban Policosanol (Raydel®) Exhibited Potent Anti-inflammatory Activity in the Liver and Protection of the Ovary and Testis with an Improvement of Blood Lipid Profile by 12 Weeks Supplementation in Hyperlipidemic Zebrafish: Comparison Study of Efficacy with Three Chinese Policosanols
Version 1
: Received: 13 July 2023 / Approved: 13 July 2023 / Online: 14 July 2023 (09:27:04 CEST)
How to cite:
Cho, K.-H.; Kim, J.-E.; Baek, S. H. Cuban Policosanol (Raydel®) Exhibited Potent Anti-inflammatory Activity in the Liver and Protection of the Ovary and Testis with an Improvement of Blood Lipid Profile by 12 Weeks Supplementation in Hyperlipidemic Zebrafish: Comparison Study of Efficacy with Three Chinese Policosanols. Preprints2023, 2023071004. https://doi.org/10.20944/preprints202307.1004.v1
Cho, K.-H.; Kim, J.-E.; Baek, S. H. Cuban Policosanol (Raydel®) Exhibited Potent Anti-inflammatory Activity in the Liver and Protection of the Ovary and Testis with an Improvement of Blood Lipid Profile by 12 Weeks Supplementation in Hyperlipidemic Zebrafish: Comparison Study of Efficacy with Three Chinese Policosanols. Preprints 2023, 2023071004. https://doi.org/10.20944/preprints202307.1004.v1
Cho, K.-H.; Kim, J.-E.; Baek, S. H. Cuban Policosanol (Raydel®) Exhibited Potent Anti-inflammatory Activity in the Liver and Protection of the Ovary and Testis with an Improvement of Blood Lipid Profile by 12 Weeks Supplementation in Hyperlipidemic Zebrafish: Comparison Study of Efficacy with Three Chinese Policosanols. Preprints2023, 2023071004. https://doi.org/10.20944/preprints202307.1004.v1
APA Style
Cho, K. H., Kim, J. E., & Baek, S. H. (2023). Cuban Policosanol (Raydel®) Exhibited Potent Anti-inflammatory Activity in the Liver and Protection of the Ovary and Testis with an Improvement of Blood Lipid Profile by 12 Weeks Supplementation in Hyperlipidemic Zebrafish: Comparison Study of Efficacy with Three Chinese Policosanols. Preprints. https://doi.org/10.20944/preprints202307.1004.v1
Chicago/Turabian Style
Cho, K., Ji-Eun Kim and Seung Hee Baek. 2023 "Cuban Policosanol (Raydel®) Exhibited Potent Anti-inflammatory Activity in the Liver and Protection of the Ovary and Testis with an Improvement of Blood Lipid Profile by 12 Weeks Supplementation in Hyperlipidemic Zebrafish: Comparison Study of Efficacy with Three Chinese Policosanols" Preprints. https://doi.org/10.20944/preprints202307.1004.v1
Abstract
Although many policosanols from different sources, such as sugar cane, rice bran, and insects, have been marketed worldwide, there has been no comparative study of the in vivo efficacy using a hyperlipidemic animal model. This study compared the efficacy of treating dyslipidemia with four different policosanols, including one sugar cane wax alcohol from Cuba (Raydel®) and three policosanols from China (Xi’an Natural sugar cane, Xi’an Realin sugar cane, and Shaanxi rice bran) in hyperlipidemic zebrafish. After 12 weeks of consumption of each policosanol (final 0.1% in diet, wt/wt) and high cholesterol diet (HCD, final 4%, wt/wt) in a tetrabit, the Raydel policosanol group and Xi’an Natural policosanol group showed the highest survivability of approximately 81%, whereas the Xi’an Realin policosanol group and Shaanxi policosanol group showed 57% and 67% survivability, respectively. Among five HCD groups, the Raydel policosanol group showed the lowest serum total cholesterol (TC, p<0.001 versus HCD control) and triglyceride (TG, p<0.001 versus HCD control) with the highest percentage of high-density lipoproteins (HDL)-C in TC. The Raydel policosanol group also showed the lowest serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels with the least infiltration of inflammatory cells and interleukin-6 production in hepatocytes. In the ovary, the Raydel policosanol group also showed the highest contents of mature vitellogenic oocytes with the lowest production of reactive oxygen species and cellular apoptosis in ovarian cells. In the testis, the Raydel policosanol group also showed the healthiest morphology for spermatogenesis with the least interstitial area and reactive oxygen species (ROS) production in testicular cells. In conclusion, 12 weeks of Raydel policosanol consumption resulted in remarkable improvement of the blood lipid profile, amelioration of inflammation in the liver, and enhancement of the cell morphology in the ovary and testis with the highest survivability under the HCD.
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