Preprint Case Report Version 2 Preserved in Portico This version is not peer-reviewed

A rare case of complete-immunotherapy-responsive metastatic NSCLC with long lasting PFS: a case report and a literature review

Claudia De Intinis
ORCID logo ,
Paolo Izzo
ORCID logo ,
Massimo Codacci-Pisanelli
,
Luciano Izzo
* ORCID logo ,
Daniela Messineo
ORCID logo ,
Simone Sibio
ORCID logo ,
Monica Champagnol
,
Silvia Lai
ORCID logo ,
Marcello Molle
ORCID logo ,
Sara Izzo
Version 1 : Received: 10 July 2023 / Approved: 10 July 2023 / Online: 11 July 2023 (10:53:55 CEST)
Version 2 : Received: 7 December 2023 / Approved: 8 December 2023 / Online: 8 December 2023 (10:10:13 CET)

A peer-reviewed article of this Preprint also exists.

De Intinis, C.; Izzo, P.; Codacci-Pisanelli, M.; Izzo, L.; Messineo, D.; Sibio, S.; Campagnol, M.; Lai, S.; Molle, M.; Izzo, S. A Rare Case of Complete-Immunotherapy-Responsive Metastatic Non-Small Cell Lung Cancer with Long Lasting Progression-Free Survival: A Case Report. Curr. Oncol. 2024, 31, 723-732. De Intinis, C.; Izzo, P.; Codacci-Pisanelli, M.; Izzo, L.; Messineo, D.; Sibio, S.; Campagnol, M.; Lai, S.; Molle, M.; Izzo, S. A Rare Case of Complete-Immunotherapy-Responsive Metastatic Non-Small Cell Lung Cancer with Long Lasting Progression-Free Survival: A Case Report. Curr. Oncol. 2024, 31, 723-732.

Abstract

Background and introduction: Lung cancer is a prevalent and deadly disease globally. Non-small cell lung cancer (NSCLC) is the most common subtype, comprising 85% of cases; Case report: A 65-year-old ex-smoker man presented to our facility with nocturnal cough. Various investigations revealed that he had metastatic NSCLC, for which he underwent chemotherapy with cisplatin and gemcitabine, followed by immunotherapy with Nivolumab. He achieved a complete response to the therapy and has remained free from recurrence for over 7 years since the initial diagnosis; Discussion and Conclusion: The treatment of metastatic NSCLC remains a significant therapeutic challenge, but the implementation of new therapeutic techniques has expanded the possibilities of achieving complete and durable eradication of the disease.

Keywords

NSCLC; metastasis; immunotherapy; complete response; case report; literature review

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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