Otunola, G.A.; Talabi, O.T.; Oduro-Yeboah, C.; Nyako, J.; Ojo, O.; Afolayan, A.J. Fermented Rice Beverages Modulate Key Enzymes Related to Type 2 Diabetes In Vitro. Preprints2023, 2023070617. https://doi.org/10.20944/preprints202307.0617.v1
APA Style
Otunola, G.A., Talabi, O.T., Oduro-Yeboah, C., Nyako, J., Ojo, O., & Afolayan, A.J. (2023). Fermented Rice Beverages Modulate Key Enzymes Related to Type 2 Diabetes In Vitro. Preprints. https://doi.org/10.20944/preprints202307.0617.v1
Chicago/Turabian Style
Otunola, G.A., Omorogieva Ojo and Anthony Jide Afolayan. 2023 "Fermented Rice Beverages Modulate Key Enzymes Related to Type 2 Diabetes In Vitro" Preprints. https://doi.org/10.20944/preprints202307.0617.v1
Abstract
Background: The therapeutic benefits of fermented foods in the treatment and prevention of Type 2 diabetes mellitus have been reported. Aim: Inhibitory effect of fermented rice beverages on α-amylase, α-glucosidase and pancreatic lipase was evaluated. Method: Two fermented rice beverages-fermented rice alone (FKR) and fermented rice plus roasted peanuts (FKRG) were produced using spontaneous fermentation. Capacity of the beverages to inhibit al-pha-glucosidase, alpha-amylase and pancreatic lipase in vitro was evaluated and compared with standards (positive controls). Results: FKR exerted inhibition of α-glucosidase between 9.23-21.11% and FKRG 1.11-17.36% at the various concentrations respectively, with both samples showing the most significant inhibition (about 20%) at 125 μg/mL. FKRG exhibited greater alpha-amylase inhibition activity than FKR, but for both samples, the most significant (P < 0.05) inhibition occurred at 500 μg/mL. With pancreatic lipase, no significant inhibition was observed for both FKR and FKRG at the tested concentrations compared to Orlistat used as control; how-ever, at 31.25 μg /mL FKRG showed an inhibitory effect of approximately 15%, which was not evident at higher concentrations. Conclusion: Low to moderate inhibition of α-amylase, α-glucosidase and pancreatic lipase by both FKR and FKRG, showed that the fermented rice beverages have potential to modulate hyperglycemia in type 2 diabetes in vitro. This is an indi-cation that fermented rice beverage could prevent postprandial hyperglycemia in vivo.
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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