Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preferential Tissue Sites of Different Cancer-risk Groups of Human Papillomaviruses

Mitsuaki Okodo
* ORCID logo ,
Kaori Okayama
ORCID logo ,
Toshiyuki Sasagawa
,
Koji Teruya
ORCID logo ,
Rei Settsu
,
Shuichi Mizuno
,
Yasuyoshi Ishii
,
Mizue Oda
Version 1 : Received: 7 July 2023 / Approved: 7 July 2023 / Online: 10 July 2023 (08:31:47 CEST)

A peer-reviewed article of this Preprint also exists.

Okodo, M.; Okayama, K.; Sasagawa, T.; Teruya, K.; Settsu, R.; Mizuno, S.; Ishii, Y.; Oda, M. Preferential Tissue Sites of Different Cancer-Risk Groups of Human Papillomaviruses. Int. J. Mol. Sci. 2023, 24, 13151. Okodo, M.; Okayama, K.; Sasagawa, T.; Teruya, K.; Settsu, R.; Mizuno, S.; Ishii, Y.; Oda, M. Preferential Tissue Sites of Different Cancer-Risk Groups of Human Papillomaviruses. Int. J. Mol. Sci. 2023, 24, 13151.

Abstract

The oncogenic potential of human papillomavirus (HPV) may be used to determine the tissue tropism of each HPV type. Cervical cancer develops in the squamo-columar junction of the cervices, and most such lesions are induced by high-risk (HR) HPV types. This suggests that HR types preferentially infect the cervix, whereas the preferential infection site for low-risk (LR) types is not well defined. Determination of HPV tropism when using cytology samples can be uncertain since it is difficult to avoid contamination of cell samples between the cervix and the vagina. Herein, cell samples were carefully collected by independently scraping the cervix and vagina, after which the HPV types were determined. HPV tissue tropism was determined by considering what HPV types were positive at only one of the sites (the cervix or the vagina) as the viruses that preferentially infected that site. This method revealed that all LR types were only identified in vaginal samples, whereas 87% of HR types were identified in cervical sites. Thus, LR types may preferentially infect the vagina, whereas HR types infect the cervix. These findings suggest that preferential tissue tropism of certain HPV types is a probable factor for malignant progression.

Keywords

human papillomavirus; tropism; contamination; cervical sample; vaginal sample

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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