Version 1
: Received: 25 June 2023 / Approved: 30 June 2023 / Online: 30 June 2023 (07:11:12 CEST)
How to cite:
Forgiarini Junior, L.A.; Forgiarini, L.F.; Mariano, R.; Paludo, A.D.O.; De Moraes, M.M.; Félix, E.A.; Andrade, C.F. Oscilatory PEEP (BiPEEP) Improves Oxygenation and Reduces Inflammation in an Experimental Model of ARDS. Preprints2023, 2023062168. https://doi.org/10.20944/preprints202306.2168.v1
Forgiarini Junior, L.A.; Forgiarini, L.F.; Mariano, R.; Paludo, A.D.O.; De Moraes, M.M.; Félix, E.A.; Andrade, C.F. Oscilatory PEEP (BiPEEP) Improves Oxygenation and Reduces Inflammation in an Experimental Model of ARDS. Preprints 2023, 2023062168. https://doi.org/10.20944/preprints202306.2168.v1
Forgiarini Junior, L.A.; Forgiarini, L.F.; Mariano, R.; Paludo, A.D.O.; De Moraes, M.M.; Félix, E.A.; Andrade, C.F. Oscilatory PEEP (BiPEEP) Improves Oxygenation and Reduces Inflammation in an Experimental Model of ARDS. Preprints2023, 2023062168. https://doi.org/10.20944/preprints202306.2168.v1
APA Style
Forgiarini Junior, L.A., Forgiarini, L.F., Mariano, R., Paludo, A.D.O., De Moraes, M.M., Félix, E.A., & Andrade, C.F. (2023). Oscilatory PEEP (BiPEEP) Improves Oxygenation and Reduces Inflammation in an Experimental Model of ARDS. Preprints. https://doi.org/10.20944/preprints202306.2168.v1
Chicago/Turabian Style
Forgiarini Junior, L.A., Elaine Aparecida Félix and Cristiano Feijo Andrade. 2023 "Oscilatory PEEP (BiPEEP) Improves Oxygenation and Reduces Inflammation in an Experimental Model of ARDS" Preprints. https://doi.org/10.20944/preprints202306.2168.v1
Abstract
Abstract: To compare the use of variable mechanical ventilation with conventional mechanical ventilation in porcine model of ARDS. Methods: Animals were divided into two groups (n = 6), conventional ventilation and variable ventilation with bi-oscillatory PEEP. For induction of ARDS, intravenous oleic acid was used until a P/F ratio of 200 to 300 mmHg. The animals were ventilated with pressure control, FiO2 1.0, inspiration-expiration ratio = 1:2, tidal volume 6 ml/kg with the initial respiratory rate adjusted to maintain an end tidal CO2 tension of 35 to 45 mmHg. Variable ventilation was characterized by the oscillation of PEEP from 5 to 10 cmH2O every 4 respiratory cycles, in convencional ventilation group PEEP was set from 5 cmH2O. Ventilatory, hemodynamic parameters, oxidative stress, antioxidant enzymes, Interleukin 8 (IL8) and 17-a (IL17a) and histological analyzes were evaluated; Results: The use of BiPEEP demonstrated improvement in lung compliance and PaO2 in relation to control. The levels of oxidative stress and antioxidant enzymes showed no significant difference. There was no difference in IL17a between groups. In IL8 there was a significant increase in the lung base of control in relation to BiPEEP, and a reduction in the apex of BiPEEP in relation to control. The control group showed changes in lung morphology characterized by cellular infiltrates, a thickening of the alveolar septae and atelectasis, which were attenuated in BiPEEP group; (4) Conclusions: The use of variable ventilation with bi-oscillatory level of PEEP demonstrates a potential ventilatory strategy in an experimental model of ARDS.
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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