Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prescribed-vs.-Taken Polypharmacy and Drug-Drug Interactions in Older Cardiovascular Patients: Observational Cross-Sectional Analytical Study

Nina D. Anfinogenova
* ,
Oksana M. Novikova
,
Irina A. Trubacheva
ORCID logo ,
Elena V. Efimova
,
Nazary P. Chesalov
,
Wladimir Y. Ussov
ORCID logo ,
Aleksandra S. Maksimova
,
Tatiana A. Shelkovnikova
,
Nadezhda I. Ryumshina
,
Irina A. Trubacheva
,
Sergey V. Popov
,
Alexei N. Repin
Version 1 : Received: 28 June 2023 / Approved: 28 June 2023 / Online: 28 June 2023 (10:34:58 CEST)

A peer-reviewed article of this Preprint also exists.

Anfinogenova, N.D.; Novikova, O.M.; Trubacheva, I.A.; Efimova, E.V.; Chesalov, N.P.; Ussov, W.Y.; Maksimova, A.S.; Shelkovnikova, T.A.; Ryumshina, N.I.; Stepanov, V.A.; Popov, S.V.; Repin, A.N. Prescribed Versus Taken Polypharmacy and Drug–Drug Interactions in Older Cardiovascular Patients during the COVID-19 Pandemic: Observational Cross-Sectional Analytical Study. J. Clin. Med. 2023, 12, 5061. Anfinogenova, N.D.; Novikova, O.M.; Trubacheva, I.A.; Efimova, E.V.; Chesalov, N.P.; Ussov, W.Y.; Maksimova, A.S.; Shelkovnikova, T.A.; Ryumshina, N.I.; Stepanov, V.A.; Popov, S.V.; Repin, A.N. Prescribed Versus Taken Polypharmacy and Drug–Drug Interactions in Older Cardiovascular Patients during the COVID-19 Pandemic: Observational Cross-Sectional Analytical Study. J. Clin. Med. 2023, 12, 5061.

Abstract

The study aimed to identify clinical pharmacology patterns of prescribed and taken medications in older cardiovascular patients using electronic health records (EHRs) (n = 704) (2019–2022). Medscape Drug Interaction Checker was used to identify pairwise drug-drug interactions (DDIs). Prevalence rates of DDIs were 73.5% and 68.5% among taken and prescribed drugs, respectively. However, total number of DDIs was significantly higher among prescribed medications compared with the list of taken drugs (p < 0.05). Serious DDIs comprised 16% and 7% of all DDIs among prescribed and taken medications, correspondingly (p < 0.05). Median DDI numbers between prescribed versus taken medications were Me = 2, IQR 0-7 and Me = 3, IQR 0-7 per record, respectively. Prevalence of polypharmacy was significantly higher among prescribed medications compared with taken medications (p < 0.05). Women were taking significantly more drugs and had higher rates of polypharmacy and DDIs (p < 0.05). No sex-related differences were observed in the list of prescribed medications. ICD code U07.1 (COVID-19, virus identified) was associated with the highest median DDI number per record. Further research is warranted to improve EHR structure, patient engagement in reporting adverse drug reactions, and genetic profiling of patients to avoid potentially serious DDIs.

Keywords

cardiovascular disease; drug-drug interaction; polypharmacy; health information system; electronic health record; epidemiology; public health

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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