Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study

Jeong Min Cho
,
Jung Hun Koh
,
Seong Geun Kim
,
Soojin Lee
,
Yaerim Kim
ORCID logo ,
Semin Cho
,
Kwangsoo Kim
ORCID logo ,
Yong Chul Kim
,
Seung Seok Han
,
Hajeong Lee
ORCID logo ,
Jung Pyo Lee
,
Kwon Wook Joo
,
Chun Soo Lim
,
Yon Su Kim
,
Dong Ki Kim
ORCID logo ,
Sehoon Park
*
Version 1 : Received: 27 June 2023 / Approved: 27 June 2023 / Online: 27 June 2023 (14:51:19 CEST)

A peer-reviewed article of this Preprint also exists.

Cho, J.-M.; Koh, J.-H.; Kim, S.-G.; Lee, S.; Kim, Y.; Cho, S.; Kim, K.; Kim, Y.-C.; Han, S.-S.; Lee, H.; Lee, J.-P.; Joo, K.-W.; Lim, C.-S.; Kim, Y.-S.; Kim, D.-K.; Park, S. Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study. Nutrients 2023, 15, 3318. Cho, J.-M.; Koh, J.-H.; Kim, S.-G.; Lee, S.; Kim, Y.; Cho, S.; Kim, K.; Kim, Y.-C.; Han, S.-S.; Lee, H.; Lee, J.-P.; Joo, K.-W.; Lim, C.-S.; Kim, Y.-S.; Kim, D.-K.; Park, S. Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study. Nutrients 2023, 15, 3318.

Abstract

The causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function remain unknown, despite being commonly used. We conducted a two-sample summary-level Mendelian randomization (MR) analysis to test for causal associations between regular dietary supplement intake and kidney function. Genetic instruments for chondroitin, glucosamine, and vitamin/mineral supplement intake were obtained from genome-wide association study of European ancestry. Summary statistics for the log-transformed estimated glomerular filtration rate (log-eGFR) were provided by the CKDGen consortium. The multiplicative random-effects inverse variance-weighted method showed that genetically predicted chondroitin and glucosamine intake was causally associated with a lower eGFR (chondroitin, eGFR change beta = -0.113 %, standard error (SE) = 0.03 %, P-value = 2E-04; glucosamine, eGFR change beta = -0.240 %, SE = 0.035 %, P-value = 6E-12). However, a genetically predicted vitamin/mineral supplement intake was associated with a higher eGFR (eGFR change beta = 1.426 %, SE = 0.136 %, P-value = 1E-25). Validation analyses and pleiotropy-robust MR results for chondroitin and vitamin/mineral supplement intake supported the main results. Our MR study suggests a potential causal effect of chondroitin and glucosamine intake on kidney function. Therefore, clinicians should carefully monitor their long-term effects.

Keywords

Chondroitin; Glucosamine; Vitamins; Minerals; Glomerular Filtration Rate

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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