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Version 1
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Angiogenesis and Lymphangiogenesis in Medulloblastoma Development
Version 1
: Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (09:28:45 CEST)
A peer-reviewed article of this Preprint also exists.
Penco-Campillo, M.; Pages, G.; Martial, S. Angiogenesis and Lymphangiogenesis in Medulloblastoma Development. Biology 2023, 12, 1028. Penco-Campillo, M.; Pages, G.; Martial, S. Angiogenesis and Lymphangiogenesis in Medulloblastoma Development. Biology 2023, 12, 1028.
Abstract
Medulloblastoma (MB) is the second most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB are highly vascularized, and both angiogenesis and lymphangiogenesis, are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways. Specifically, we will focus on the role and mechanism of action of VEGFC, one of the key players in lymphangiogenesis.
Keywords
Medulloblastoma; childhood; angiogenesis; lymphangiogenesis, VEGFC
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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