Version 1
: Received: 20 June 2023 / Approved: 21 June 2023 / Online: 21 June 2023 (16:02:04 CEST)
How to cite:
Mishra, A.; Mishra, P.; Mishra, V. Gut Microbiome and Diabetes – A Bibliometric and Narrative Review. Preprints2023, 2023061578. https://doi.org/10.20944/preprints202306.1578.v1
Mishra, A.; Mishra, P.; Mishra, V. Gut Microbiome and Diabetes – A Bibliometric and Narrative Review. Preprints 2023, 2023061578. https://doi.org/10.20944/preprints202306.1578.v1
Mishra, A.; Mishra, P.; Mishra, V. Gut Microbiome and Diabetes – A Bibliometric and Narrative Review. Preprints2023, 2023061578. https://doi.org/10.20944/preprints202306.1578.v1
APA Style
Mishra, A., Mishra, P., & Mishra, V. (2023). Gut Microbiome and Diabetes – A Bibliometric and Narrative Review. Preprints. https://doi.org/10.20944/preprints202306.1578.v1
Chicago/Turabian Style
Mishra, A., Pallavi Mishra and Vinaytosh Mishra. 2023 "Gut Microbiome and Diabetes – A Bibliometric and Narrative Review" Preprints. https://doi.org/10.20944/preprints202306.1578.v1
Abstract
Gut microbiota is a complex and dynamic ecosystem that influences various aspects of human health. Unfortunately, there is a lack of literature highlighting the importance of gut microbiome especially in diabetes management. This paper performs bibliometric analysis to establish the rising interest of researchers in this area and the importance of gut microbiota in diabetes management. Subsequently, the study performs a narrative review to provide an overview of the gut microbiota consisting of bacteria, archaea, fungi, and viruses, and its diversity, composition, and variation among individuals. The paper further discusses the role of the gut microbiota in different diseases, including Clostridium difficile infection, behavioral disorders, cancer, obesity, diabetes, atherosclerosis, and inflammatory bowel disease, among others. It emphasizes the link between gut dysbiosis (imbalanced gut microbiota) and the development of chronic metabolic disorders. Additionally, the paper discusses the factor negatively impacting the gut microbiota. The paper concludes by explaining the mechanistic abnormalities that link dysbiosis to type 2 diabetes, including changes in short-chain fatty acid production, amino acid metabolism, bile acid regulation, and the production of specific bacterial products. Thus, the paper highlights the importance of understanding gut microbiota and related mechanisms for developing therapeutic interventions targeting the gut microbiota.
Keywords
Gut Microbiota; Dysbiosis; Endocrine; Diabetes; Therapeutic
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
