Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cost-Utility of Monulpiravir in COVID-19 Treatment: An Estimation in Vietnam Situation

Nam Xuan Vo
* ORCID logo ,
Ngan Nguyen Hoang Le
,
Trinh Dang Phuong Chu
,
Huong Lai Pham
,
Khang Xuan An Dinh
,
Tu Kim Tran
,
Tien Thuy Bui
Version 1 : Received: 21 June 2023 / Approved: 21 June 2023 / Online: 21 June 2023 (15:34:48 CEST)

How to cite: Vo, N. X.; Le, N. N. H.; Chu, T. D. P.; Pham, H. L.; Dinh, K. X. A.; Tran, T. K.; Bui, T. T. Cost-Utility of Monulpiravir in COVID-19 Treatment: An Estimation in Vietnam Situation. Preprints 2023, 2023061574. https://doi.org/10.20944/preprints202306.1574.v1 Vo, N. X.; Le, N. N. H.; Chu, T. D. P.; Pham, H. L.; Dinh, K. X. A.; Tran, T. K.; Bui, T. T. Cost-Utility of Monulpiravir in COVID-19 Treatment: An Estimation in Vietnam Situation. Preprints 2023, 2023061574. https://doi.org/10.20944/preprints202306.1574.v1

Abstract

The COVID-19 pandemic has expanded globally and caused serious consequence in both health system and the economy. MPV is one of two oral antivirals for COVID-19 with mild-to-moderate symptoms that have received FDA approval so far. This study aims to evaluate the cost-utility of using MPV in COVID-19 treatment. To compare the utility costs of MPV and non-MPV treatments for COVID-19 patients, we used a decision tree model. Data on clinical efficacy, cost, and quality of life were gathered from previous studies. The incremental effective cost ratio (ICER) calculated based on costs incurred and quality-adjusted life years (QALY), was considered as primary out-come. The total cost of MPV treatment and not using MPV was 15,362,516 VND (618 USD) and 15,771,262 VND (634 USD), respectively. The estimated QALY with using-MPV was 28.33, while without MPV was 19.72. The ICER was dominant, resulting in savings of 47,453 VND/QALY (1.9 USD). MPV is a cost-effective medication used to treat COVID-19. In mild-to-moderate COVID-19 patients, MPV considerably lowers costs and improves quality of life. However, several clinical factors of the drug still need to be taken into account.

Keywords

Cost-utility; Covid-19; Molnupiravir; Vietnam; Utility

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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