Version 1
: Received: 20 June 2023 / Approved: 21 June 2023 / Online: 21 June 2023 (11:01:48 CEST)
How to cite:
D’Agostino, S.; Valentini, G.; Iarussi, F.; Dolci, M. Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review. Preprints2023, 2023061535. https://doi.org/10.20944/preprints202306.1535.v1
D’Agostino, S.; Valentini, G.; Iarussi, F.; Dolci, M. Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review. Preprints 2023, 2023061535. https://doi.org/10.20944/preprints202306.1535.v1
D’Agostino, S.; Valentini, G.; Iarussi, F.; Dolci, M. Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review. Preprints2023, 2023061535. https://doi.org/10.20944/preprints202306.1535.v1
APA Style
D’Agostino, S., Valentini, G., Iarussi, F., & Dolci, M. (2023). Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review. Preprints. https://doi.org/10.20944/preprints202306.1535.v1
Chicago/Turabian Style
D’Agostino, S., Francesca Iarussi and Marco Dolci. 2023 "Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review" Preprints. https://doi.org/10.20944/preprints202306.1535.v1
Abstract
Diabetes may cause an increase blood levels of cytokines inducing a rising of C reactive protein (PCR) and fibrinogen stimulating a subclinical inflammation which lead to adhesive molecules expression and to endothelial disfunction. A comprehensive panel of type 1 diabetes mellitus (T1DM) interleukins polymorphisms is not provided yet. As chronic periodontitis (CP) is considered the sixth complication of DM, a clarification is needed about the inflammatory role managed by single nucleotides polymorphisms (SNPs). The goal of this review is to focus on the significant diversity of SNPs in T1DM patients with and without CP. After a digital search on PubMed and Scopus with reference to the last 5 years, 21 items were enrolled. Several ILs were analyzed. T1DM still needs to be thoroughly explored regarding the ILs polymorphisms panel, however the last 5 years have led to the increased independence of this condition, causing autonomous inflammatory effects which requires further investigations. CP and T1DM association in children and adolescents represents a severe gap in literature that should be filled, the scarce presence of studies also about adults serves as a motivation for ulterior clinical researches
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
