van Zwol, W.; van de Sluis, B.; Ginsberg, H.N.; Kuivenhoven, J.A. VLDL Biogenesis and Secretion: It Takes a Village. Circulation Research 2024, 134, 226–244, doi:10.1161/circresaha.123.323284.
van Zwol, W.; van de Sluis, B.; Ginsberg, H.N.; Kuivenhoven, J.A. VLDL Biogenesis and Secretion: It Takes a Village. Circulation Research 2024, 134, 226–244, doi:10.1161/circresaha.123.323284.
van Zwol, W.; van de Sluis, B.; Ginsberg, H.N.; Kuivenhoven, J.A. VLDL Biogenesis and Secretion: It Takes a Village. Circulation Research 2024, 134, 226–244, doi:10.1161/circresaha.123.323284.
van Zwol, W.; van de Sluis, B.; Ginsberg, H.N.; Kuivenhoven, J.A. VLDL Biogenesis and Secretion: It Takes a Village. Circulation Research 2024, 134, 226–244, doi:10.1161/circresaha.123.323284.
Abstract
The production and secretion of very-low density lipoproteins (VLDL) by hepatocytes has a direct impact on liver fat content as well as the concentration of cholesterol and triglycerides in the circulation and thus affects liver and cardiovascular health, respectively. Importantly, excess caloric intake and lack of physical activity are associated with overproduction of VLDL, hepatic steatosis, and increased levels of atherogenic lipoproteins. Cholesterol as well as triglycerides in remnant particles after VLDL lipolysis are risk factors for atherosclerotic cardiovascular disease (ASCVD) and have garnered increasing attention over the last few decades. To date, however, increased risk of ASCVD is not the only concern when considering today’s cardiometabolic patients, as they often also suffer from hepatic steatosis. This notion highlights the importance of understanding the molecular regulation of VLDL biogenesis. Fortunately, there has been a resurgence of interest in the intracellular assembly, trafficking, degradation, and secretion of VLDL by hepatocytes, that has led to many exciting new molecular insights, the topic of this review. We think that increasing our understanding of the biology of this pathway will help improve the health of the cardiometabolic patient in the long term.
Keywords
Very low density lipoproteins; biogenesis; dyslipidemia
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
