Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Serum Level of Ceruloplasmin, Angiotensin Converting Enzyme and Transferin as Markers of Severity in SARS-Cov-2 Infection in Patients With Type 2 Diabetes

Patricia Restea
ORCID logo ,
Ștefan Țigan
,
Laura Grațiela Vicaș
* ,
Luminita Fritea
* ,
Eleonora Marian
ORCID logo ,
Tünde Jurca
ORCID logo ,
Annamaria Pallag
ORCID logo ,
Iulius Liviu Mureșan
,
Corina Moisa
,
Otilia Micle
,
Mariana Muresan
Version 1 : Received: 19 June 2023 / Approved: 19 June 2023 / Online: 19 June 2023 (16:29:47 CEST)

How to cite: Restea, P.; Țigan, Ș.; Vicaș, L.G.; Fritea, L.; Marian, E.; Jurca, T.; Pallag, A.; Mureșan, I.L.; Moisa, C.; Micle, O.; Muresan, M. Serum Level of Ceruloplasmin, Angiotensin Converting Enzyme and Transferin as Markers of Severity in SARS-Cov-2 Infection in Patients With Type 2 Diabetes. Preprints 2023, 2023061377. https://doi.org/10.20944/preprints202306.1377.v1 Restea, P.; Țigan, Ș.; Vicaș, L.G.; Fritea, L.; Marian, E.; Jurca, T.; Pallag, A.; Mureșan, I.L.; Moisa, C.; Micle, O.; Muresan, M. Serum Level of Ceruloplasmin, Angiotensin Converting Enzyme and Transferin as Markers of Severity in SARS-Cov-2 Infection in Patients With Type 2 Diabetes. Preprints 2023, 2023061377. https://doi.org/10.20944/preprints202306.1377.v1

Abstract

The aim of this study was to analyze other possible new markers of severity that can be assessed in patients with type 2 diabetes and SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) infection. Our study included 90 subjects: 45 patients with type 2 diabetes mellitus and infected with the SARS-CoV-2 virus, and 45 healthy persons as control. The serum level of ceruloplasmin at hospital admission was statistically significant directly correlated with the severity of COVID-19 (Coronavirus disease) (p=0.037) and with the serum level of IL-6 (Interleukine 6) (p=0.000). Ceruloplasmin was statistically significant inversely correlated with serum iron level (p=0.000). However, we observed that ACE (Angiotensin converting enzyme) decreased in severe forms of the infection with SARS-CoV-2 virus in patients with type 2 diabetes (p=0.001). Moreover, the decrease in ACE level was correlated with an increase in IL-6 level in these patients (p=0.001). IL-6 increase was statistically significant inversely correlated with serum iron, transferrin and ACE levels. There was a noticed a decreasing tendency of the transferrin depending on the severity of the COVID-19 infection (p=0.000). In addition to the known severity factors in the context of infection with the new coronavirus, decreased concentrations of ceruloplasmin, ACE and transferrin may represent new markers of COVID-19 severity in patients with type 2 diabetes. These parameters analyzed at the hospital admission could show the evolution towards the severe forms of infection with the SARS-CoV-2 virus.

Keywords

ceruloplasmin; Angiotensin Converting Enzyme; IL-6, transferrin; COVID-19; type 2 diabetes; SARS-CoV-2; serum iron

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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