Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Sequential and Combined Efficacious Management of Auricular keloid: A Novel Treatment Protocol Employing Ablative CO2 and Dye Laser Therapy – An Advanced Single-Center Clinical Investigation

Simone Amato
* ORCID logo ,
Steven Paul Nisticò
,
Giovanni Pellacani
,
Stefania Guida
,
Anthony Rossi
,
Caterina Longo
,
Enzo Berardesca
,
Giovanni Cannarozzo
Version 1 : Received: 15 June 2023 / Approved: 16 June 2023 / Online: 16 June 2023 (13:46:19 CEST)

A peer-reviewed article of this Preprint also exists.

Amato, S.; Nisticò, S.P.; Pellacani, G.; Guida, S.; Rossi, A.; Longo, C.; Berardesca, E.; Cannarozzo, G. Sequential and Combined Efficacious Management of Auricular Keloid: A Novel Treatment Protocol Employing Ablative CO2 and Dye Laser Therapy—An Advanced Single-Center Clinical Investigation. Cosmetics 2023, 10, 126. Amato, S.; Nisticò, S.P.; Pellacani, G.; Guida, S.; Rossi, A.; Longo, C.; Berardesca, E.; Cannarozzo, G. Sequential and Combined Efficacious Management of Auricular Keloid: A Novel Treatment Protocol Employing Ablative CO2 and Dye Laser Therapy—An Advanced Single-Center Clinical Investigation. Cosmetics 2023, 10, 126.

Abstract

Auricular keloids pose significant aesthetic and functional challenges, and traditional treatments often fall short in ad-dressing these. Our study presents an innovative combined approach of ablative CO2 and dye laser therapy for improved keloid management. This treatment protocol was applied to 15 patients with auricular keloids after an initial multispec-tral analysis to assess keloid composition. The laser sequence was tailored per patient based on this analysis. Evalua-tions using the Vancouver Scar Scale and Patient and Observer Scar Assessment Scale were carried out at baseline and at 3-week intervals post-treatment. The results showed a significant reduction in these scores at the final follow-up (p<0.05), suggesting improvements in keloid color, texture, and pliability, with minimal adverse events. Additionally, no recur-rence of keloids was observed. Our findings indicate that this novel methodology of multispectral analysis followed by tailored laser therapy may offer a safe and effective solution for auricular keloids, promising enhanced keloid treatment and prevention of recurrence. However, further investigations, including randomized controlled trials, are needed to confirm and optimize this treatment protocol.

Keywords

Auricular keloids, CO2 laser therapy, Dye laser therapy, Multispectral analysis; scar; Vancouver scar scale; Patient and Observer Scar Assessment Scale

Subject

Medicine and Pharmacology, Dermatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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