Gharari, Z.; Hanachi, P.; Sadeghinia, H.; Walker, T.R. Eco-Friendly Green Synthesis and Characterization of Silver Nanoparticles by Scutellaria multicaulis Leaf Extract and Its Biological Activities. Pharmaceuticals2023, 16, 992.
Gharari, Z.; Hanachi, P.; Sadeghinia, H.; Walker, T.R. Eco-Friendly Green Synthesis and Characterization of Silver Nanoparticles by Scutellaria multicaulis Leaf Extract and Its Biological Activities. Pharmaceuticals 2023, 16, 992.
Gharari, Z.; Hanachi, P.; Sadeghinia, H.; Walker, T.R. Eco-Friendly Green Synthesis and Characterization of Silver Nanoparticles by Scutellaria multicaulis Leaf Extract and Its Biological Activities. Pharmaceuticals2023, 16, 992.
Gharari, Z.; Hanachi, P.; Sadeghinia, H.; Walker, T.R. Eco-Friendly Green Synthesis and Characterization of Silver Nanoparticles by Scutellaria multicaulis Leaf Extract and Its Biological Activities. Pharmaceuticals 2023, 16, 992.
Abstract
Scutellaria multicaulis, a member of the Lamiaceae, is a medicinal plant indigenous to Iran, Afghanistan, and Pakistan. It has been widely used as a prominent herb in traditional medicine for thousands of years. This plant is reported with baicalein, wogonin, and chrysin flavonoids as a significant group of chemical ingredients, which can cure different diseases such as breast cancer. S. multicaulis leave extract was used for the bioreduction of silver nanoparticles (SmL-Ag-NPs), and their phytochemical contents and antioxidant, antibacterial, anti-proliferative, and apoptotic activity were evaluated. Optimal physicochemical properties of SmL-Ag-NPs were obtained by mixing 5% of leave extract and 2 mM of aqueous AgNO3 solution and confirmed by characterization studies including UV–visible spectrophotometry, FE-SEM, EDX, DLS, zeta potential, TGA, SERS, XRD and FTIR Spectroscopy. SmL-Ag-NPs exhibited higher content of TPC (Total Phenolic Content) and TFC (Total Flavonoid Content) and potential antioxidant activity. SmL-Ag-NPs also demonstrated dose-dependent cytotoxicity against MDA-MB231 cells multiplication with an IC50 value of 37.62 μg/mL at 48h through inducing cell apoptosis. This is the first report on the biosynthesis of silver nanoparticles using S. multicaulis leave extract, which can provide treatment for cancer diseases and reduce some negative effects of chemotherapy.
Keywords
Apoptotic; Cytotoxicity; Green synthesis; Nanostructures; Scutellaria multicaulis; Silver
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
