Version 1
: Received: 13 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (14:18:40 CEST)
How to cite:
Portela, P.; Bermúdez-Moretti, M.; Ortolá Martínez, M.C.; Galello, F.; Rossi, S. Stress Responses in Saccharomyces cerevisiae: The Role of PKA Signalling Pathway. Preprints2023, 2023061054. https://doi.org/10.20944/preprints202306.1054.v1
Portela, P.; Bermúdez-Moretti, M.; Ortolá Martínez, M.C.; Galello, F.; Rossi, S. Stress Responses in Saccharomyces cerevisiae: The Role of PKA Signalling Pathway. Preprints 2023, 2023061054. https://doi.org/10.20944/preprints202306.1054.v1
Portela, P.; Bermúdez-Moretti, M.; Ortolá Martínez, M.C.; Galello, F.; Rossi, S. Stress Responses in Saccharomyces cerevisiae: The Role of PKA Signalling Pathway. Preprints2023, 2023061054. https://doi.org/10.20944/preprints202306.1054.v1
APA Style
Portela, P., Bermúdez-Moretti, M., Ortolá Martínez, M.C., Galello, F., & Rossi, S. (2023). Stress Responses in<em> Saccharomyces cerevisiae</em>: The Role of PKA Signalling Pathway. Preprints. https://doi.org/10.20944/preprints202306.1054.v1
Chicago/Turabian Style
Portela, P., Fiorella Galello and Silvia Rossi. 2023 "Stress Responses in<em> Saccharomyces cerevisiae</em>: The Role of PKA Signalling Pathway" Preprints. https://doi.org/10.20944/preprints202306.1054.v1
Abstract
The yeast Saccharomyces cerevisiae is widely used in food and nonfood industries. During industrial fermentations yeast are exposed to fluctuations in oxygen concentration, osmotic pressure, pH, ethanol concentration, nutrient availability and temperature. Fermentation performance depends on the ability of different yeast strains to adapt to these changes. Suboptimal growth conditions trigger responses to these external stimuli to allow cellular homeostasis to be maintained. Stress-specific signaling pathways are activated to coordinate changes in tran-scription, translation, protein function, and metabolic fluxes while a transient arrest of growth and cell cycle progression occur. cAMP-PKA, HOG-MAPK and CWI signalling pathways are signal transduction pathways turned on during stress re-sponse. Comprehension of the mechanisms involved in the responses and in the adaptation to these stresses during fermentation is key to improving this industrial process. The scope of this review is to outline the advancement of knowledge about the cAMP-PKA signalling and the crosstalk of this pathway with the CWI and HOG-MAPK cascades in response to the environmental challenges heat and hy-perosmotic stress.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
