Kim, H.K.; Kim, C.J.; Jang, D.; Lim, D.-H. MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila. Insects 2023, 14, 709. https://doi.org/10.3390/insects14080709
Kim, H.K.; Kim, C.J.; Jang, D.; Lim, D.-H. MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila. Insects 2023, 14, 709. https://doi.org/10.3390/insects14080709
Kim, H.K.; Kim, C.J.; Jang, D.; Lim, D.-H. MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila. Insects 2023, 14, 709. https://doi.org/10.3390/insects14080709
Kim, H.K.; Kim, C.J.; Jang, D.; Lim, D.-H. MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila. Insects 2023, 14, 709. https://doi.org/10.3390/insects14080709
Abstract
The hematopoietic system plays a crucial role in immune defense response and normal development, and is regulated by various factors from other tissues. The dysregulation of hematopoiesis is associated with melanotic mass formation; however, the molecular mechanisms underlying this process are poorly understood. Here, we observed that the overexpression of miR-274 in the fat body resulted in the formation of melanotic masses. Moreover, abnormal activation of the JNK and JAK/STAT signaling pathways was linked to these consequences. In addition to this defect, miR-274 overexpression in the larval fat body decreased the total tissue mass, leading to a reduction in body weight. miR-274-5p was found to directly suppress the expression of found-in-neurons (fne), which encodes an RNA-binding protein. Similar to the effects of miR-274 overexpression, fne depletion led to melanotic mass formation and growth reduction. Collectively, miR-274 plays a regulatory role in the fne-JNK signaling axis in melanotic mass formation and growth control.
Biology and Life Sciences, Cell and Developmental Biology
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